Sökning: "Göran Widmalm"

Visar resultat 1 - 5 av 28 avhandlingar innehållade orden Göran Widmalm.

  1. 1. Structural studies of bacterial polysaccharides using specific degradations, NMR spectroscopy and CASPER, a computerized approach

    Författare :Göran Widmalm; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  2. 2. Structural Studies of O-Polysaccharides from Diarrhoeal Escherichia coli

    Författare :Tara Ali; Göran Widmalm; Andrej Weintraub; Lennart Kenne; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; Lipopolysaccharide; NMR; biological repeating unit; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis describes the structural analysis of O-polysaccharides from the Gram-negative bacterium Escherichia coli that is a diarrhoeal pathogen. The Escherichia coli serotypes investigated were O178, O171, O166 and O128. The methods used in these studies were nuclear magnetic resonance spectroscopy and component analysis. LÄS MER

  3. 3. Assembling and Unraveling Carbohydrates Structures : Conformational analysis of synthesized branched oligosaccharides

    Författare :Thibault Angles d'Ortoli; Göran Widmalm; Christian Marcus Pedersen; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Convergent carbohydrate synthesis; Super-armed donors; Glycosylation; Conformational analysis; NMR; Chemical shift prediction; Organic Chemistry; organisk kemi;

    Sammanfattning : Advances in the elaboration of vaccines and enzyme inhibitors rely on acquiring more knowledge about protein-carbohydrate binding events. Furthermore, the relationships between biological function and the three-dimensional properties of large glycans can be studied by focusing on the structural components they contained, namely, by scaling down the system under analysis. LÄS MER

  4. 4. Dynorphin A – Interactions with receptors and the membrane bilayer

    Författare :Johannes Björnerås; Lena Mäler; Astrid Gräslund; Göran Widmalm; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biophysics; biofysik; biokemi; Biochemistry;

    Sammanfattning : The work presented in this thesis concerns the dynorphin neuropeptides, and dynorphin A (DynA) in particular. DynA belongs to the wider class of typical opioid peptides that, together with the opioid receptors, a four-membered family of GPCR membrane proteins, form the opioid system. LÄS MER

  5. 5. Physicochemical and Structural Aspects of Nucleic Acids

    Författare :Subhrangsu Chatterjee; Adolf Gogoll; Helena Grennberg; Göran Widmalm; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; pKa; Hydrogen bonding; Stacking; NMR; MD; DNA; RNA; Pyrimidine; Organisk kemi;

    Sammanfattning : This thesis consists of seven research publications concerning (i) pKa studies of nucleobases in model nucleotides to understand why RNA duplexes are more stable than DNA duplexes (Paper I), (ii) the role of Me(T)-π interactions in the relative stability of DNA-RNA heteroduplexes (Paper II), (iii) pKa measurements in nucleotides with different 2′-substituents (paper III), (iv) a conformation study of constrained sugars and a pKa study of 1-thyminyl to reveal effect of sugar constraints on the pKa of the nucleobase (paper IV), (v) NMR and MD studies of 1′, 2′-oxetane constrained thymidine incorporated Dickerson Drew dodecamer (paper V), (vi) the sequence dependent pKa perturbation of 9-guaninyl moeity in single stranded (ss) DNA and RNA (paper VI), (vii) the non identical chemical nature of internucleotidic phosphates in (ss) RNA using 31P NMR (paper VI), and an alkaline hydrolysis study of phosphodiesters in ssRNAs (paper VII). The architecture of DNA and RNA molecules is determined by (a) hydrogen bonding (b) base stacking (c) a variety of additional non-covalent interactions. LÄS MER