Sökning: "electrophiles"

Visar resultat 21 - 25 av 37 avhandlingar innehållade ordet electrophiles.

1. 21. Evolutionary Analysis and Posttranslational Chemical Modifications in Protein Redesign : A Study on Mu Class Glutathione Transferases

   Författare :Ylva Ivarsson; Bengt Mannervik; Gun Stenberg; Richard N. Armstrong; Uppsala universitet; []
   Nyckelord :Biochemistry; glutathione transferase; evolutionary analysis; positive selection; epoxide; stereoselectivity; protein modification; Biokemi;

   Sammanfattning : Glutathione transferases (GSTs) constitute a family of multifarious enzymes that conjugate glutathione (GSH) with a wide range of electrophiles. GSTs are grouped into different classes based on protein sequence similarities. Despite high sequence identities between GSTs of the same class they often display different substrate specificites. LÄS MER

3. 22. Reaction Between Grignard reagents and Heterocyclic N-oxides : Synthesis of Substituted Pyridines, Piperidines and Piperazines

   Författare :Hans Andersson; Fredrik Almqvist; Hans Adolfsson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Grignard reagents; pyridine N-oxide; pyrazine N-oxide; dienal-oxime; pyridine; ortho- metalation; piperidine; piperazine; asymmetric; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis describes the development of new synthetic methodologies for preparation of bioactive interesting compounds, e.g. substituted pyridines, piperidines or piparazines. Thesecompounds are synthesized from commercially available, cheap and easily prepared reagents, videlicet the reaction between Grignard reagents and heterocyclic N-oxides. LÄS MER

4. 23. Transition metal-catalysed hydrogen transfer processes for C-C and C-N bond formation : Synthetic studies and mechanistic investigations

   Författare :Agnieszka Bartoszewicz; Belen Martin-Matute; Martin Albrecht; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hydrogen transfer; catalysis; transition metal; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis focusses on synthetic studies and mechanistic investigations into reactions involving hydrogen-transfer processes.In the first part, the development of an efficient method for the synthesis of β-hydroxy ketones (aldols) and β-amino ketones (Mannich products) from allylic alcohols and aldehydes is described. LÄS MER

5. 24. Supernucleophilic Cob(I)alamin : analytical tool for genotoxic compounds in vitro and in vivo

   Författare :Johanna Haglund; Eddy Esmans; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; toxikologisk genetik; Genetic Toxicology;

   Sammanfattning : The low but still non-acceptable levels of exposure to genotoxic compounds emphasises the need for sensitive methods for searching, detecting, identifying and quantifying these compounds. Within the field of studies on genotoxic compounds, chemically quantitative work is required throughout. LÄS MER

7. 25. Equine glutathione transferase A3-3 : an efficient steroid isomerase

   Författare :Helena Lindström; Bengt Mannervik; Ann-Kristin Östlund Farrants; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Equine; glutatione transferase; steroidogenesis; steroid isomerase; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Glutathione transferases (GSTs) comprise a superfamily of enzymes prominently involved in detoxication by making toxic electrophiles more polar and therefore more easily excretable. However some GSTs have developed alternative functions. LÄS MER