Sökning: "electrophiles"

Visar resultat 6 - 10 av 37 avhandlingar innehållade ordet electrophiles.

  1. 6. Catalytic Functionalization of Allylic Substrates by Palladium Pincer Complexes

    Författare :Nicklas Selander; Kálmán Szabó; David Milstein; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Catalysis; Palladium; Pincer Complex; Boron; Multicomponent Reaction; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis is based on the development of novel catalytic reactions for the synthesis and application of organometallic reagents. The main focus is directed towards organoboronate derivatives. We developed an efficient procedure for converting allylic alcohols to the corresponding allylboronates using palladium pincer complexes as catalysts. LÄS MER

  3. 7. Iron catalyzed C-C coupling reactions - mechanistic investigations

    Författare :Anna Hedström; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; iron; homogenous catalysis; cross coupling; C-C bond formation; reaction mechanisms; kinetic investigations; competitive Hammett study; density functional theory;

    Sammanfattning : The mechanism of the iron catalyzed cross coupling of aryl electrophiles with alkyl Grignard reagents was studied. The reaction proceeds via a rate-limiting oxidative addition of the aryl halide to an Fe(I) complex generated in situ. A transmetalation from an aryl Grignard reagent occurs either before or after the oxidative addition. LÄS MER

  4. 8. Synthesis of a targeted library and thrombin inhibitors using organometallic chemistry

    Författare :Fredrik Thorstensson; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The use of organometallic chemistry in the pursuit of novel scaffolds is outline d. A 4-phenyl- 2-carboxy-piperazine targeted combinatorial chemistry library has been synthesized aimed at the early lead discovery phase. LÄS MER

  5. 9. Probing the Alpha Class Glutathione Transferase Structure. Combinatorial Subunit Studies and Rational Redesign

    Författare :Ann Gustafsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Glutathione transferases; rational redesign; enzyme; catalysis; Biokemi; Biochemistry; Biokemi; Molecular Biotechnology; molekylär bioteknik avd f jonfysik ;

    Sammanfattning : The present work concerns two Alpha class enzymes, GST A1-1 and GST A4-4, of the glutathione transferase (GST) family, which are detoxication enzymes catalyzing the conjugation of the tripeptide glutathione with various electrophiles. The GST A1-1 structure was explored for protein engineering purposes and tailored for increased activity toward alkenals. LÄS MER

  7. 10. General Protocols for the Preparation of Tröger's Base Analogues and Molecular Recognition by Designed Tröger's Base Receptors

    Författare :Jacob Jensen; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; non-covalent bonds.; molecular recognition; desymmetrization; metal-mediated reactions; Tröger s base; synthetic protocols;

    Sammanfattning : 2,8-Dihalo substituted analogues of Tröger’s base were prepared via the Tröger’s base condensation reaction. These compounds were used as synthetic intermediates for the preparation of otherwise inaccessible functionalized Tröger’s base analogues. LÄS MER