Sökning: "combinatorial synthesis"
Visar resultat 1 - 5 av 38 avhandlingar innehållade orden combinatorial synthesis.
1. Combinatorial Synthesis of Pilicides
Sammanfattning : This thesis describes a combinatorial approach to design and synthesis of three libraries of compounds, referred to as pilicides, designed to target periplasmic chaperones present in uropathogenic Escherichia coli bacteria that are the main cause of urinary tract infections. Periplasmic chaperones are required for assembly of adhesive organelles, i. LÄS MER
2. Structure-Based Design and Synthesis of Protease Inhibitors Using Cycloalkenes as Proline Bioisosteres and Combinatorial Syntheses of a Targeted Library
Sammanfattning : Structure-based drug design and combinatorial chemistry play important roles in the search for new drugs, and both these elements of medicinal chemistry were included in the present studies. This thesis outlines the synthesis of protease inhibitors against thrombin and the HCV NS3 protease, as well as the synthesis of a combinatorial library using solid phase chemistry. LÄS MER
3. Methodological studies in solid phase synthesis : Linkers and applications of multi-component condensations
Sammanfattning : Solid phase synthesis has become an increasingly important tool in the synthesis of oligopolymers and small organic molecules. This thesis covers three important areas in the solid phase synthesis technique: linker strategies, reduction methods and novel routes to complex heterocycles. LÄS MER
4. Discovery-Oriented Screening of Dynamic Systems: Combinatorial and Synthetic Applications
Sammanfattning : This thesis is divided into six parts, all centered around the development of dynamic (i.e., reversibly interacting) systems of molecules and their applications in dynamic combinatorial chemistry (DCC) and organic synthesis. LÄS MER
5. Compositional Approaches in Supervisory Control with Application to Automatic Generation of Robot Interlocking Policies
Sammanfattning : The work presented in this thesis concerns verification and synthesis in the Ramadge and Wonham supervisory control framework. Supervisory control constitutes a formal framework for the design of supervisors for discrete event systems. LÄS MER