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Visar resultat 1 - 5 av 23 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Vesicle-mediated and free soluble delivery of bacterial effector proteins by oral and systemic pathogens

   Författare :Bernard Thay; Jan Oscarsson; Mikael Rhen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Periodontitis; Aggregatibacter actinomycetemcomitans; Staphylococcus aureus; membrane vesicles; vesicle-host cell interaction; protein delivery; molekylärbiologi; Molecular Biology;

   Sammanfattning : Periodontitis, the primary cause of tooth-loss worldwide, is a bacterially induced chronic inflammatory disease of the periodontium. It is associated with systemic conditions such as cardiovascular disease (CVD). However, pathogenic mechanisms of periodontitis-associated bacteria that may contribute to the CVD association are unclear. LÄS MER

3. 2. YopD translocator function in Yersinia pseudotuberculosis type III secretion

   Författare :Tiago R. D. Costa; Matthew S. Francis; William D. Picking; Umeå universitet; []
   Nyckelord :Y. pseudotuberculosis; T3SS; translocon; YopD; coiled-coil; effector delivery; regulation; virulence; mikrobiologi; Microbiology;

   Sammanfattning : Type III secretion systems (T3SS) are a common feature of Gram-negative bacteria, allowing them to inject anti-host effectors into the interior of infected eukaryotic cells. By this mechanism, these virulence factors help the bacteria to modulate eukaryotic cell function in its favor and subvert host innate immunity. LÄS MER

4. 3. Harnessing the molecular Trojan horse : Evaluating properties of preclinical Aβ immunoPET radioligands for optimized brain delivery via the transferrin receptor

   Författare :Gillian Bonvicini; Stina Syvänen; Johanna Fälting; Dag Sehlin; Ken Honek; Sahar Roshanbin; Joy Zuchero; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transferrin receptor TfR ; bispecific antibody; brain delivery; positron emission tomography PET ; Alzheimer’s disease; pharmacokinetics; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

   Sammanfattning : With high specificity and selectivity to targets, antibodies are prime candidates for positron emission tomography (PET) radioligands. They do not passively cross the blood-brain barrier which has hindered their development for imaging intrabrain targets, like amyloid-β (Aβ) in Alzheimer’s disease. LÄS MER

5. 4. Delivery of TypeIII Secreted Toxins by Yersinia pseudotuberculosis : the Role of LcrV, YopD, and Free Lipids in the Translocation Process

   Författare :Jan Olsson; Hans Wolf-Watz; Ina Attree; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Yersinia; T3SS; translocation; YopD; LcrV; YLC; fatty acids.; Molecular biology; Molekylärbiologi;

   Sammanfattning : Bacteria that infect humans and animals face a hard combat with the host´s immune system and in order to establish infection, pathogenic bacteria has evolved mechanisms to avoid being cleared from the host tissue. Many Gram-negatives carry a Type 3 secretion (T3S) system that is used to deliver effector proteins (toxins) into host cells. LÄS MER

7. 5. Engineering more efficient multipotent mesenchymal stromal (stem) cells for systemic delivery as cellular therapy

   Författare :Guido Moll; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :multipotent mesenchymal stromal stem cell;

   Sammanfattning : Do mesenchymal progenitor cells naturally circulate in vivo? Are they fundamentally compatible with blood? What mechanism allows them to be in contact with blood? How do we make therapeutic cells with blood-compatible properties? Can we optimise their survival and therapeutic function upon systemic delivery? How should we best isolate and condition therapeutic multipotent mesenchymal stromal (stem) cells (MSCs) before infusion, to achieve an optimum and sustainable clinical response in patients? This thesis covers many aspects related to these questions. It describes how MSCs interact with the instant blood-mediated inflammatory reaction (IBMIR) upon infusion. LÄS MER