Sökning: "Guido Moll"

Hittade 1 avhandling innehållade orden Guido Moll.

1. 1. Engineering more efficient multipotent mesenchymal stromal (stem) cells for systemic delivery as cellular therapy

   Författare :Guido Moll; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :multipotent mesenchymal stromal stem cell;

   Sammanfattning : Do mesenchymal progenitor cells naturally circulate in vivo? Are they fundamentally compatible with blood? What mechanism allows them to be in contact with blood? How do we make therapeutic cells with blood-compatible properties? Can we optimise their survival and therapeutic function upon systemic delivery? How should we best isolate and condition therapeutic multipotent mesenchymal stromal (stem) cells (MSCs) before infusion, to achieve an optimum and sustainable clinical response in patients? This thesis covers many aspects related to these questions. It describes how MSCs interact with the instant blood-mediated inflammatory reaction (IBMIR) upon infusion. LÄS MER