Sökning: "Ken Honek"

Hittade 1 avhandling innehållade orden Ken Honek.

1. 1. Harnessing the molecular Trojan horse : Evaluating properties of preclinical Aβ immunoPET radioligands for optimized brain delivery via the transferrin receptor

   Författare :Gillian Bonvicini; Stina Syvänen; Johanna Fälting; Dag Sehlin; Ken Honek; Sahar Roshanbin; Joy Zuchero; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transferrin receptor TfR ; bispecific antibody; brain delivery; positron emission tomography PET ; Alzheimer’s disease; pharmacokinetics; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

   Sammanfattning : With high specificity and selectivity to targets, antibodies are prime candidates for positron emission tomography (PET) radioligands. They do not passively cross the blood-brain barrier which has hindered their development for imaging intrabrain targets, like amyloid-β (Aβ) in Alzheimer’s disease. LÄS MER