Sökning: "T3SS"

Visar resultat 1 - 5 av 26 avhandlingar innehållade ordet T3SS.

  1. 1. YopD translocator function in Yersinia pseudotuberculosis type III secretion

    Författare :Tiago R. D. Costa; Matthew S. Francis; William D. Picking; Umeå universitet; []
    Nyckelord :Y. pseudotuberculosis; T3SS; translocon; YopD; coiled-coil; effector delivery; regulation; virulence; mikrobiologi; Microbiology;

    Sammanfattning : Type III secretion systems (T3SS) are a common feature of Gram-negative bacteria, allowing them to inject anti-host effectors into the interior of infected eukaryotic cells. By this mechanism, these virulence factors help the bacteria to modulate eukaryotic cell function in its favor and subvert host innate immunity. LÄS MER

  2. 2. Multiple twists in the molecular tales of YopD and LcrH in type III secretion by Yersinia pseudotuberculosis

    Författare :Petra J Edqvist; Matthew Francis; Olaf Schneewind; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Yersinia pseudotuberculosis; T3SS; YopD; translocation process; LcrH; class II chaperone; substrate secretion pathway specificity; Molecular biology; Molekylärbiologi;

    Sammanfattning : The type III secretion system (T3SS) is a highly conserved secretion system among Gram negative bacteria that translocates anti-host proteins directly into the infected cells to overcome the host immune system and establish a bacterial infection. Yersinia pseudotuberculosis is one of three pathogenic Yersinia spp. LÄS MER

  3. 3. Controlling substrate export by the Ysc-Yop type III secretion system in Yersinia

    Författare :Ayad Amer; Matthew Francis; David L. Gally; Umeå universitet; []
    Nyckelord :Y. pseudotuberculosis; T3SS; YscX; YopD; assembly; translation control; temporal secretion.; mikrobiologi; Microbiology;

    Sammanfattning : Several pathogenic Gram-negative bacteria invest in sophisticated type III secretion systems (T3SS) to incapacitate their eukaryotic hosts. T3SSs can secrete protein cargo outside the bacterial cell and also target many of them into the eukaryotic cell interior. LÄS MER

  4. 4. Molecular mechanisms of Yersinia pseudotuberculosis for adaptation and establishment of infection in host tissue

    Författare :A. K. M. Firoj Mahmud; Maria Fällman; Matthew S. Francis; Javier Pizarro-Cerda; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; RpoN; T3SS; RNA-Seq; Biofilm; Transcription; Yersinia; Data analysis; ChIP-Seq; biology; biologi;

    Sammanfattning : Bacterial pathogens can evade the host’s immune defence to adapt and establish an infection within the host. Some even slip into a quiescent state to establish themselves without acutely harming the host. Phylogenetically unrelated bacteria can share similar strategies for the establishment of infection and for persistence. LÄS MER

  5. 5. Controlling virulence in Yersinia pseudotuberculosis through accumulation of phosphorylated CpxR

    Författare :Edvin Thanikkal; Matthew Francis; Andrew Darwin; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Y. pseudotuberculosis; CpxA; CpxR; invasin; RovA; RovM; T3SS; virulence; transcriptional regulation; molekylärbiologi; Molecular Biology; mikrobiologi; Microbiology;

    Sammanfattning : Like many Gram-negative bacteria, the food-borne pathogen Yersinia pseudotuberculosis harbours different regulatory mechanisms to maintain an intact bacterial envelope especially during exposure to extracytoplasmic stress (ECS). The CpxA-CpxR two component regulatory system is one such ECS-responsive regulatory mechanism. LÄS MER