Sökning: "disease progression"

Visar resultat 36 - 40 av 1144 avhandlingar innehållade orden disease progression.

1. 36. Vertigo as a companion through life : Empirical studies regarding psychological factors in Menière's disease

   Författare :Christina Hägnebo; Uppsala universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Psychology; coping; emotions; Menière s disease; psychology; quality of life; stress; Psykologi; Psychology; Psykologi; klinisk psykologi; Clinical Psychology;

   Sammanfattning : Vertigo, tinnitus and hearing impairment constitute the cardinal symptoms in Menière'sdisease. This inner ear disorder, the aetiology of which is not fully understood, may causeconsiderable distress to the individual. Previous psychological research regardingMenière's disease has mainly focused on general personality traits. LÄS MER

3. 37. Complement in Disease - Extracellular Proteins as Complement Regulators

   Författare :Kaisa Happonen; Malmö Proteinkemi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; joint disease; Complement; proteoglycan; cancer;

   Sammanfattning : Complement activation occurs during inflammatory joint diseases such as rheumatoid arthritis (RA) and is thought to contribute to the chronic inflammation observed within the joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. LÄS MER

4. 38. Preclinical PET imaging and therapy of Alzheimer's disease

   Författare :Silvio R. Meier; Stina Syvänen; Dag Sehlin; Greta Hultqvist; Matthias Brendel; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; positron emission tomography PET ; bispecific antibody; BACE-1; TREM2; GFAP; Molekylär medicin; Molecular Medicine; Neuroscience; Neurovetenskap;

   Sammanfattning : The main histopathological hallmarks of Alzheimer’s disease are extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles, containing tau protein. Because of misfolded and aggregated proteins, activated microglia and astroglia react with a neuroinflammatory response, which may contribute to disease progression and severity. LÄS MER

5. 39. Search for Biomarkers in ALS and Parkinson's Disease : Positron Emission Tomography and Cerebrospinal Fluid Studies

   Författare :Anders Johansson; Håkan Askmark; Lennart Persson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyotrophic lateral sclerosis; ALS; Parkinson’s disease; cerebrospinal fluid; positron emission tomography; vascular endothelial growth factor; fibroblast growth factor 2; proteomics; Fourier transform ion cyclotron resonance mass spectrometry; deprenyl-D2; PIB; FDG; L-[β11C]-DOPA; Neurology; Neurologi; Neurology; neurologi;

   Sammanfattning : New biomarkers are needed to improve knowledge about pathophysiology, in order to provide earlier correct diagnosis and to follow disease progression of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). The aim of this thesis was to find new biomarkers for these diseases. LÄS MER

7. 40. New Approaches for Levodopa Treatment in Parkinson’s Disease

   Författare :Marina Senek; Dag Nyholm; Elisabet I Nielsen; Maral Mouradian; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; Pharmacokinetics; Pharmacodynamics; Population modeling; Levodopa; Carbidopa; Entacapone; Microtablets; Intestinal infusion;

   Sammanfattning : Parkinson’s disease (PD) is characterized by degeneration of dopaminergic cells, which results in dopamine depletion. Levodopa is the most effective symptomatic treatment, however, disease progression along with the unfavorable pharmacokinetics of levodopa makes the disease increasingly difficult to treat with time. LÄS MER