Sökning: "joint disease"

Visar resultat 1 - 5 av 265 avhandlingar innehållade orden joint disease.

  1. 1. Psoriatic arthritis: a complex disease : analyses on genetic and serological biomarkers and of comorbidity

    Författare :Kristina Juneblad; Gerd-Marie Alenius; Solbritt Rantapää-Dahlqvist; Lars-Erik Kristenssen; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psoriatic Arthritis; genetics; inflammasomes; polymorphisms; biomarkers; disease expression; disease activity; cardiovascular diseases; mortality; epidemiology;

    Sammanfattning : Psoriatic Arthritis (PsA) is a heterogonous inflammatory arthritis associated with psoriasis. The disease leads to inflammation of peripheral joints, axial skeleton and/or enthesites, and can result in severe destruction of affected joints. LÄS MER

  3. 2. Joint disease biomarkers - discovery and application

    Författare :Dovilė Sinkevičiūtė; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; Osteoarthritis; Psoriatic arthritis; cartilage; Proteomics; Biomarkers; ELISA; Tissue culture; Extracellular matrix ECM ;

    Sammanfattning : Dysregulated cartilage homeostasis, articular cartilage degradation and abnormal bone remodeling are common denominators in joint disease and can lead to severe disability for the patients. The molecular pathways behind the disease pathology can overlap across different joint diseases. LÄS MER

  4. 3. Complement in Disease - Extracellular Proteins as Complement Regulators

    Författare :Kaisa Happonen; Malmö Proteinkemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; joint disease; Complement; proteoglycan; cancer;

    Sammanfattning : Complement activation occurs during inflammatory joint diseases such as rheumatoid arthritis (RA) and is thought to contribute to the chronic inflammation observed within the joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. LÄS MER

  5. 4. Staphylococcal prosthetic joint infections : similar, but still different

    Författare :Staffan Tevell; Bo Söderquist; Åsa Nilsdotter-Augustinsson; Annelies Zinkernagel; Örebro universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prosthetic joint infections; staphylococcal infections; nasal carriage; Staphylococcus aureus; Staphylococcus epidermidis; Staphylococcus capitis; NRCS-A; antibiotic resistance; heterogeneous glycopeptide resistance; whole-genome sequencing; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : Staphylococci constitute a major part of our commensal flora but are also the most common bacteria causing prosthetic joint infections (PJIs), a dreaded complication of arthroplasty surgery. However, not all staphylococci are the same. LÄS MER

  7. 5. Predictors of disease onset and progression in early rheumatoid arthritis : A clinical, laboratory and radiological study

    Författare :Ewa Berglin; Solbritt Rantapää-Dahlqvist; Thomas Skogh; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; early; rheumatoid; arthritis; anti-CCP; antibodies; factors; radiological; outcome; disease; onset; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; medicin; Medicine;

    Sammanfattning : To diagnose rheumatoid arthritis (RA) during the early stages of the disease is often difficult. The disease course shows great inter-individual variation from mild, self-limiting to very severe destruc-tive disease with extra-articular manifestations. LÄS MER