Sökning: "Intestinal infusion"

Visar resultat 1 - 5 av 30 avhandlingar innehållade orden Intestinal infusion.

  1. 1. Intestinal transport of levodopa : Implications for the therapy of Parkinson's disease

    Författare :Dag Nilsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; levodopa. duodenal Infusion; intestinal permeability; positron emission tomography; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Sammanfattning : Levodopa has been the basic treatment of patients with Parkinson's disease for the last 30 years. However, with time nearly all patients develop fluctuations in motor performance correlated to levodopa plasma concentrations. LÄS MER

  3. 2. Pharmacotherapy for Parkinson's Disease - Observations and Innovations

    Författare :Dag Nyholm; Sten-Magnus Aquilonius; Andrew Lees; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; levodopa; pharmacokinetics; infusion; drug delivery systems; electronic patient diary; Neurovetenskap; Neurology; Neurologi; Neurology; Neurologi;

    Sammanfattning : Pharmacotherapy for Parkinson’s disease (PD) is based on levodopa, the most effective dopaminergic drug. The development of motor complications constitutes the major challenge for new or refined therapies. LÄS MER

  4. 3. Decision Support for Treatment of Patients with Advanced Parkinson’s Disease

    Författare :Jerker Westin; Torgny Groth; Mark Dougherty; Sven Pålhagen; Marja-Liisa Dahl; Martin Rydmark; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; telemedicine; motor test; tapping; spiral; self-assessment; home-assessment; outcome measure; electronic diary; patient-reported outcome; remote patient monitoring; levodopa; infusion; pharmacokinetic; pharmacodynamic; Medical informatics; Medicinsk informatik; Medical Informatics; Medicinsk informatik; E-MOTIONS; Beslutsstöd för Parkinsonbehandling;

    Sammanfattning : The overall aim of this thesis was to develop, deploy and evaluate new IT-based methods for supporting treatment and assessment of treatment of advanced Parkinson’s disease. In this condition a number of different motor and non-motor symptoms occur in episodes of varying frequency, duration and severity. LÄS MER

  5. 4. New Approaches for Levodopa Treatment in Parkinson’s Disease

    Författare :Marina Senek; Dag Nyholm; Elisabet I Nielsen; Maral Mouradian; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s disease; Pharmacokinetics; Pharmacodynamics; Population modeling; Levodopa; Carbidopa; Entacapone; Microtablets; Intestinal infusion;

    Sammanfattning : Parkinson’s disease (PD) is characterized by degeneration of dopaminergic cells, which results in dopamine depletion. Levodopa is the most effective symptomatic treatment, however, disease progression along with the unfavorable pharmacokinetics of levodopa makes the disease increasingly difficult to treat with time. LÄS MER

  7. 5. Developmental and methodological aspects of intestinal and pancreatic function in pigs and rats

    Författare :Klas Rådberg; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; macromolecule; endocytosis; FITC-dextran; secretion; mucosa; CCK; pancreas; disaccharidase; intestinal permeability; lectin; morphometry; Animal physiology; Djurfysiologi;

    Sammanfattning : The gastrointestinal tract has two opposing functions; to effectively absorb nutrients and to act as a safety barrier against hazardous substances in the environment. After birth these functions develops gradually. LÄS MER