Sökning: "disease determinants"

Visar resultat 6 - 10 av 225 avhandlingar innehållade orden disease determinants.

1. 6. Early life dietary factors on the risk of celiac disease. Associations of dietary factors with risk of celiac disease in children at genetic risk

   Författare :Elin M Hård af Segerstad; Celiaki och diabetes; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Celiac Disease; Celiac disease autoimmunity; Gluten; Nutrition epidemiology; Dietary Intake; Children’s health; human leucocyte antigen; Transglutaminase Antibodies; The Environmental Determinants of Diabetes in the Young TEDDY ; Dietary patterns; Milk powder; Gluten-containing grains; Food records;

   Sammanfattning : .... LÄS MER

3. 7. Genetic and molecular determinants in inflammatory bowel disease

   Författare :Francesca Bresso; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Inflammatory Bowel Disease, IBD, are polygenic disorders that present itself to the clinician as a sum of interacting events arising from multiple factors of genetic, immunological and environmental origin, resulting in a chronic relapsing inflammation that manifests itself in two major forms, ulcerative colitis (UC) and Crohn Ls disease (CD). Shortage of reliable biomarkers for correct diagnosis and thus appropriate treatment regime is still a major problem for the clinically active physician. LÄS MER

4. 8. Genetic Determinants of Dyslipidemia

   Författare :Tibor V Varga; Genetisk och molekylär epidemiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetic epidemiology; Genetic polymorphism; dyslipidaemia; Cholesterol; Triglyceride; Genetic risk; genetic risk score; Single nucleotide polymorphism; Prediction; Gene-environment interactions; Randomized controlled trial; prospective cohort studies; Observational study; GLACIER Study; Diabetes Prevention Program;

   Sammanfattning : Dyslipidemia is a chronic deviation from normal blood lipid levels that can lead to atherosclerosis and other cardiovascular diseases; dyslipidemia and its sequelae are caused by the complex interplay of genetic and environmental factors. Although circulating concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (LDL-C) have a strong genetic underpinning, not much is known about the genetic factors that affect long-term deteriorations in lipid concentrations. LÄS MER

5. 9. Inflammatory bowel disease : determinants related to gut microbiota

   Författare :Ali Kiasat; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Inflammatory bowel disease (IBD) is a chronic and idiopathic disorder that causes inflammation in the gastrointestinal tract. Overall, it can be classified into two types: ulcerative colitis (UC) and Crohn's disease (CD). LÄS MER

7. 10. Molecular determinants of disease severity in urinary tract infection

   Författare :Ines Ambite; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Asymptomatic bacteriuria; urinary tract infection; acute pyelonephritis; cystitis; Escherichia coli 83972; host response; NlpD; RNA Polymerase II; transcription regulation; inflammasome; Il-1β; ASC; NLRP-3; hyper-inflammatory disorder; MMP-7; IL-1RA; genetic susceptibility; IRF-7; siRNA therapy; P fimbriae; type 1 fimbriae;

   Sammanfattning : In the urinary tract, Escherichia coli infection may result in life-threatening disease, or asymptomatic bacterial carriage, comparable to bacterial commensalism in the gut. Pathogenic strains trigger a disease provoking host response which differs depending on the infected organ. LÄS MER