Sökning: "Lars Ekholm"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Lars Ekholm.

  1. 1. Soluble amyloid-β aggregates in Alzheimer’s disease

    Författare :Hillevi Englund; Frida Ekholm Pettersson; Lars NG Nilsson; Lars Lannfelt; Dominic M Walsh; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Geriatrics and medical gerontology; Geriatrik och medicinsk gerontologi; Geriatrics; geriatrik;

    Sammanfattning : Soluble oligomeric aggregates of the amyloid-β (Aβ) peptide are suggested to initiate Alzheimer's disease (AD), leading to impaired synapse signalling, widespread neuronal death and loss of cognitive functions. These aggregates seem tightly linked to disease progression, and have therefore gained much attention as potential novel disease markers. LÄS MER

  2. 2. Targeting Early Stages of Alzheimer’s Disease in a Transgenic Model

    Författare :Anna Lord; Lars Nilsson; Lars Lannfelt; Frida Ekholm Pettersson; Thomas Bayer; Uppsala universitet; []
    Nyckelord :Geriatrics; geriatrik;

    Sammanfattning : The Arctic mutation causes early-onset Alzheimer’s disease (AD), and makes amyloid-β (Aβ) peptides more prone to form Aβ protofibrils. The aims of this thesis were to investigate the mechanisms of the Arctic mutation in vivo, and to use transgenic models to determine the role of early intermediates of Aβ aggregation, like protofibrils, in the pathogenesis. LÄS MER

  3. 3. Svensk krigsfinansiering 1630-1631

    Författare :Lars Ekholm; Uppsala universitet; []
    Nyckelord :HUMANITIES; HUMANIORA; HUMANIORA; HUMANITIES; History; Historia;

    Sammanfattning : .... LÄS MER

  4. 4. Identical, But Still Different : On Artistic Appropriation in Visual Art

    Författare :Rikard Ekholm; Claes Entzenberg; Lars-Olof Åhlberg; Sven-Olov Wallenstein; Uppsala universitet; []
    Nyckelord :HUMANITIES; HUMANIORA; HUMANIORA; HUMANITIES; Visual art; artistic appropriation; intention; context; meta-art; conceptual art; art theory; philosophy of art; Danto; Sturtevant; Levine; Mandiberg.; Estetik; Aesthetics;

    Sammanfattning : In this dissertation about artistic appropriation I acknowledge that something indeed has happened in art. Visual art does not have to look in any special way anymore, or have historically validated content that can be visually grasped. Within this precondition artistic appropriation is situated. LÄS MER

  5. 5. Amyloid-β Protofibril Formation and Neurotoxicity : Implications for Alzheimer’s Disease

    Författare :Ann-Sofi Johansson; Lars Lannfelt; Frida Ekholm Pettersson; Pär Gellerfors; Tobias Hartmann; Uppsala universitet; []
    Nyckelord :Neurosciences; Amyloid-β; Neurotoxicity; Aggregation; Protofibrils; Alzheimer s disease; Neurovetenskap;

    Sammanfattning : Alzheimer’s disease (AD) is the most common cause of dementia. A characteristic feature of AD is the presence of amyloid plaques in the cortex and hippocampus of the brain. The principal component of these plaques is the amyloid-β (Aβ) peptide, a cleavage product from proteolytic processing of amyloid precursor protein (APP). LÄS MER