Sökning: "Il-1β"

Visar resultat 1 - 5 av 165 avhandlingar innehållade ordet Il-1β.

  1. 1. Role of Inducible Nitric Oxide Synthase and Melatonin in Regulation of β-cell Sensitivity to Cytokines

    Författare :Annika K. Andersson; Stellan Sandler; Nils Welsh; Décio L. Eizirik; Nils Billestrup; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; β-cell; Cyclooxygenase; Cytokine; Diabetes; IFN-γ; IL-1β; iNOS; Insulin; Melatonin; Nitric oxide; Pancreatic islets; Phospholipase D; Prostaglandin E2; Streptozotocin; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : The mechanisms of β-cell destruction leading to type 1 diabetes are complex and not yet fully understood, but infiltration of the islets of Langerhans by autoreactive immune cells is believed to be important. Activated macrophages and T-cells may then secrete cytokines and free radicals, which could selectively damage the β-cells. LÄS MER

  3. 2. Innate immunity in human atherosclerosis and myocardial infarction : Role of CARD8 and NLRP3

    Författare :Geena Paramel Varghese; Karin Fransén; Allan Sirsjö; Liza Ljungberg; Johan Frostegård; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atherosclerosis; Inflammasome; NLRP3; CARD8; Myocardial infarction; Endothelial cells; Polymorphism; IL-1β; Cytokines; Innate immunity; Biomedicin; Biomedicine;

    Sammanfattning : Atherosclerosis is complex inflammatory disease of the arterial wall with progressive accumulation of lipids and narrowing of the vessel. Increasing evidence suggest that inflammation plays an important role in plaque stability and often accelerate cardiovascular events such as myocardial infarction (MI). LÄS MER

  4. 3. Inflammatory cell death of human macrophages induced by Aggregatibacter actinomycetemcomitans leukotoxin

    Författare :Peyman Kelk; Anders Johansson; Charels A Dinarello; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aggregatibacter actinomycetemcomitans; leukotoxin; IL-1β; caspase-1; inflammatory cell death; pyroptosis; ODONTOLOGY; ODONTOLOGI; odontologi; Odontology;

    Sammanfattning : Aggregatibacter (Actinobacillus) actinomycetemcomitans is a bacterium mainly associated with aggressive forms of periodontitis. Among its virulence factors, a leukotoxin is suggested to play an important role in the pathogenicity. LÄS MER

  5. 4. Influence of inflammation and of stage of lung development on the development of neonatal lung injury

    Författare :Erica Bäckström; Göteborgs universitet; []
    Nyckelord :premature birth; BPD; inflammation; IL-1β; lung development; gastric aspirates;

    Sammanfattning : Bronchopulmonary dysplasia (BPD) is a major cause of mortality and long-term morbidity in prematurely born infants. Pulmonary inflammation, and abnormal alveolar and vascular development of the lung are histological characteristics of BPD. Interleukin (IL)-1β is a central cytokine in inflammation. LÄS MER

  7. 5. Plasticity and Inflammation following Traumatic Brain Injury

    Författare :Anders Hånell; Niklas Marklund; Lars Hillered; Nikolaus Plesnila; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic Brain Injury; plasticity; inflammation; Nogo receptor; EphA4; IL-1β; Neurosurgery; Neurokirurgi; Neuroscience; Neurovetenskap;

    Sammanfattning : Traumatic Brain Injury (TBI) mainly affects young persons in traffic accidents and the elderly in fall accidents. Improvements in the clinical management have significantly improved the outcome following TBI but survivors still suffer from depression, memory problems, personality changes, epilepsy and fatigue. LÄS MER