Avancerad sökning

Visar resultat 6 - 10 av 23 avhandlingar som matchar ovanstående sökkriterier.

  1. 6. Starch Microparticles as an Oral Vaccine Adjuvant with Emphasis on the Differentiation of the Immune Response

    Författare :Linda Stertman; Ingvar Sjöholm; Kjell-Olov Grönvik; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Vaccine adjuvant; Microparticles; Oral immunisation; Th1 Th2 differentiation; Mucosal immune response; Uptake; M cell; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : Polyacryl starch microparticles have been developed as an oral vaccine adjuvant capable of inducing strong local and systemic immune responses in mice. In this thesis, the starch microparticles were studied in order to increase basic understanding of their function. LÄS MER

  3. 7. Epidemiological characterisation of Bordatella pertussis in Sweden, 1970-2004

    Författare :Abdolreza Advani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Worldwide, Bordetella pertussis causes some 50 million cases of pertussis, and an estimated 2-300,000 fatalities each year. In Sweden vaccination against pertussis was introduced in the 1950s using diphtheria-tetanus-whole-cell pertussis vaccine (DTPw) until 1979, when it was withdrawn due to concerns about effectiveness. LÄS MER

  4. 8. Det hotade barnet : Tre generationers spädbarns- och barnadödlighet i 1800-talets Linköping

    Författare :Magdalena Bengtsson; Linköpings universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; infant mortality; child mortality; family history; 19th century; urban mortality; historical demography; Sweden; INTERDISCIPLINARY RESEARCH AREAS; TVÄRVETENSKAPLIGA FORSKNINGSOMRÅDEN;

    Sammanfattning : This study deals with the decline in infant and child mortality in Sweden during the 19th century. Around 1800 about a quarter of all children died before the age of one and 100 years later the proportion had been reduced to one tenth. LÄS MER

  5. 9. Synthesis of Small Molecules Targeting ADP-Ribosyltransferases and Total Synthesis of Resveratrol Based Natural Products

    Författare :Anders Lindgren; Mikael Elofsson; Nicholas Westwood; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organic synthesis; quinazolinone; ARTD; PARP; total synthesis; polyphenols; bensofuranes; organisk kemi; Organic Chemistry;

    Sammanfattning : Diphtheria Toxin-like ADP-RibosyltransferasesThe Human ADP-ribosyl transferases (ARTDs) are a group of poorly studied enzymes which are believed to be involved in e.g. DNA repair, protein degradation, transcription regulation and cell death. Medicinal chemistry programmes aimed at developing selective inhibitors of these ARTDs were initiated. LÄS MER

  7. 10. Adverse Reactions after Vaccination and Allergen-Specific Immunotherapy: Contact Allergy to Aluminium and Itching Nodules

    Författare :Eva Netterlid; Yrkes- och miljödermatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Patch test; Itching nodules; Contact allergy; ASIT; Aluminium; Allergen-specific immunotherapy; Adverse event; Parental reports; vaccination;

    Sammanfattning : The aim of the work presented in this thesis was to investigate two different types of adverse reactions, persistent itching nodules and contact allergy to aluminium, after immunization with aluminium-containing vaccines and aluminium-containing allergen extracts used for allergen-specific immunotherapy (ASIT). The first paper describes active parental reporting of adverse events (AEFIs) after a booster dose of diphtheria-tetanus vaccine (DT). LÄS MER