Sökning: "Oral immunisation"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Oral immunisation.

  1. 1. Starch Microparticles as an Oral Vaccine Adjuvant with Emphasis on the Differentiation of the Immune Response

    Författare :Linda Stertman; Ingvar Sjöholm; Kjell-Olov Grönvik; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Vaccine adjuvant; Microparticles; Oral immunisation; Th1 Th2 differentiation; Mucosal immune response; Uptake; M cell; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : Polyacryl starch microparticles have been developed as an oral vaccine adjuvant capable of inducing strong local and systemic immune responses in mice. In this thesis, the starch microparticles were studied in order to increase basic understanding of their function. LÄS MER

  3. 2. Passive immunisation as therapy for gastrointestinal infections in children

    Författare :Thomas Casswall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Passive immunisation; treatment; bovine antibodies; chicken antibodies; rotavirus; Escherichia coli; ETEC; EPEC; Helicobacter pylori; clinical trials; infants; children;

    Sammanfattning : Several prophylactic studies in animals and humans have shown potential efficacy of oral therapy with non-human antibodies against different pathogens. Passive immunisation with oral antibodies against different pathogens is an attractive way to treat different gastrointestinal infections caused by pathogens such as rotavirus or enteropathogenic and enterotoxigenic Escherichia coli (EPEC; ETEC). LÄS MER

  4. 3. Group B streptococcus capsular polysaccharide - Cholera toxin B subunit conjugate vaccine for mucosal immunisation : development and preclinical evaluation of experimental conjugate vaccines

    Författare :Xuzhuang Shen; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Group B streptococci (GBS) can colonize the female genital and rectal tracts and cause invasive infection in susceptible newborns. An optimally effective GBS vaccine should induce both mucosal and systemic immunity. LÄS MER

  5. 4. Mucosal Vaccination Using Polyacryl Starch Microparticles as Adjuvant with Salmonella enteritidis as a Model Pathogen

    Författare :Lena Strindelius; Ingvar Sjöholm; Mary Jo Wick; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; mucosal vaccination; polyacryl starch microparticles; salmonella enteritidis; flagellin; fimbriae; rCTB; LPS; Ussing chamber; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : Polyacryl starch microparticles have been developed as a new mucosal vaccine adjuvant intended for use in oral vaccination. The main objectives of this thesis were to evaluate the efficacy of these polyacryl starch microparticles and to study their uptake through mucosal tissues. LÄS MER

  7. 5. Studies of molecular events during peripheral B cell differentiation

    Författare :Jens Wrammert; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; Immunology; B cells; Differentiation;

    Sammanfattning : This thesis focuses on molecular changes occuring during terminal B cell differentiation as well as on somatic hypermutation and the generation and maintenance of B cell memory. During T cell dependent immune responses the average affinity for the eliciting antigen increases with time. LÄS MER