Sökning: "digital native"

Visar resultat 31 - 35 av 89 avhandlingar innehållade orden digital native.

  1. 31. Acute limb ischaemia : Treatment, outcome and time trends

    Författare :Olivia Grip; Martin Bjöck; Clark Zeebregts; Uppsala universitet; []
    Nyckelord :Acute limb ischaemi; Treatment; Open revascularisation; Endovascular revascularisation; Outcome; Surgery; Kirurgi;

    Sammanfattning : Acute limb ischaemia (ALI) is a frequent emergency associated with high rates of amputation and death. Traditionally, patients with ALI were treated with open surgical removal of the occlusion or bypass surgery. During the past few decades, new endovascular techniques developed. LÄS MER

  3. 32. Exploring evolutionary and chemical space using chemoinformatic tools and traditional methods in pharmacognosy

    Författare :Astrid Henz Ryen; Anders Backlund; Thierry Kogej; Fernando B. Da Costa; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; angiosperm chemistry; physicochemical properties of plant specialized metabolites; chemical diversity; chemical space; sesquiterpene lactones; scaffold diversity; molecular framework; cluster analysis; ECFP6; Lindera benzoin; sesquiterpenes; anti-inflammatory; Farmakognosi; Pharmacognosy;

    Sammanfattning : The number of new drugs coming to the market is declining while interest in lead discovery from natural resources is seeing a revival. Although methods for isolation and identification of natural products have advanced tremendously, methods for selection of potential leads have fallen behind. LÄS MER

  4. 33. Clinically-driven angiography after coronary artery bypass surgery : Results from the SWEDEHEART registry

    Författare :Mikael Janiec; Rickard Lindblom; Stefan Thelin; Alexander Wahba; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CABG; Coronary artery bypass surgery; angiography; graft failure; Thorax Surgery; Thoraxkirurgi;

    Sammanfattning : The success of coronary artery bypass grafting (CABG) arguably depends on the patency rate of the conduits. The saphenous vein grafts (SVGs) most often used are subject to graft disease and their reduced long-term patency compared to left internal mammary artery (IMA) grafts is well established. LÄS MER

  5. 34. Exploring the Role of the PDZ Domain in a Supramodule

    Författare :Louise Laursen; Per Jemth; Per Hammarström; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PSD-95; PSG; PDZ3; supramodule; liquid liquid phase separation; allostery; folding; binding; evolution; post synaptic density; SynGap; CRIPT; AGRB1; Medical Biochemistry; Medicinsk biokemi; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : The postsynaptic density (PSD) is a large, dense and membraneless compartment of proteins associated below the postsynaptic membrane bilayer, and which constantly undergoes morphological alteration in response to synaptic activity. Formation of PSD is associated with liquid-liquid phase separation of scaffold proteins in complex with other PSD proteins. LÄS MER

  7. 35. Molecular Mechanisms of Folding and Binding in PDZ Domains

    Författare :Syed Raza ul Haq; per jemth; Daniel Otzen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : PDZ domains are one of the most abundant protein-protein interaction modules that mediate protein recognition by binding to short amino acid sequences in the cells. These globular protein domains usually consist of 80-100 amino acid residues that fold into six ß-strands and two a-helices. LÄS MER