Sökning: "post synaptic density"
Visar resultat 1 - 5 av 11 avhandlingar innehållade orden post synaptic density.
1. Post-synaptic Density Disc Large Zo-1 (PDZ) Domains : From Folding and Binding to Drug Targeting
Sammanfattning : Understanding how proteins fold and bind is interesting since these processes are central to most biological activity. Protein folding and protein-protein interaction are by themselves very complex but using a good and robust system to study them could ease some of the hurdles. LÄS MER
2. Exploring the Role of the PDZ Domain in a Supramodule
Sammanfattning : The postsynaptic density (PSD) is a large, dense and membraneless compartment of proteins associated below the postsynaptic membrane bilayer, and which constantly undergoes morphological alteration in response to synaptic activity. Formation of PSD is associated with liquid-liquid phase separation of scaffold proteins in complex with other PSD proteins. LÄS MER
3. Advanced Fluorescence Microscopy to Study Plasma Membrane Protein Dynamics
Sammanfattning : Membrane protein dynamics is of great importance for living organisms. The precise localization of proteins composing a synapse on the membrane facing a nerve terminus is essential for proper functioning of the nervous system. In muscle fibers, the nicotinic acetylcholine is densely packed under the motor nerve termini. LÄS MER
4. Morphological and immunohistochemical studies on the organisation of sacral motoneurons
Sammanfattning : The aim of this thesis was to study pre- and postsynaptic elements during postnatal development and aging. Motoneurons from two adjacent sacral motor nuclei in the cat spinal cord were investigated: the motoneurons innervating intrinsic foot-sole muscles (dorsolateral motor nucleus; DLN) and the motoneurons innervating striated perineal muscles (Onufs nucleus, ventrolateral motor nucleus; VLN). LÄS MER
5. Alzheimer's disease : towards a multifaceted approach in neuropathological diagnosis
Sammanfattning : The main aim of this study has been to investigate potential neuropathological features which may play an important role in understanding the cognitive dysfunction and in making the final diagnosis of Alzheimer's disease (AD). To establish a reliable diagnosis of AD, standardisation and uniformity of the diagnostic protocols must become mandatory. LÄS MER