Sökning: "digital native"

Visar resultat 41 - 45 av 89 avhandlingar innehållade orden digital native.

1. 41. Bending, Twisting and Turning : Protein Modeling and Visualization from a Gauge-Invariance Viewpoint

   Författare :Martin Lundgren; Antti Niemi; Jørgen Ellegaard Andersen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein folding; discrete frenet frame; solitons; protein visualization; Physics and Astronomy specializing in Theoretical Physics; Fysik och astronomi med inriktning mot teoretisk fysik;

   Sammanfattning : Proteins in nature fold to one dominant native structure. Despite being a heavily studied field, predicting the native structure from the amino acid sequence and modeling the folding process can still be considered unsolved problems. In this thesis I present a new approach to this problem with methods borrowed from theoretical physics. LÄS MER

3. 42. Electronic Structure Calculations of Point Defects in Semiconductors

   Författare :Andreas Höglund; Susanne Mirbt; Alison Mainwood; Uppsala universitet; []
   Nyckelord :Physics; electronic structure calculations; point defects; semiconductor; formation energy; equilibrium solubility limit; thermodynamic equilibrium concentration; transfer levels; negative-U; 110 surface; diffusion; activation energy; solar cells; Fysik;

   Sammanfattning : In this thesis point defects in semiconductors are studied by electronic structure calculations. Results are presented for the stability and equilibrium concentrations of native defects in GaP, InP, InAs, and InSb, for the entire range of doping conditions and stoichiometry. LÄS MER

4. 43. Gas-Phase Protein Structure Under the Computational Microscope : Hydration, Titration, and Temperature

   Författare :Erik Marklund; David van der Spoel; Albert Heck; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular dynamics; gas phase; proteins; micelles; proton transfer; Grothuss mechanism; kinetics; Physics; Fysik; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

   Sammanfattning : Although the native environment of the vast majority of proteins is a complex aqueous solution, like the interior of a cell, many analysis methods for assessing chemical and physical properties of biomolecules require the sample to be aerosolized; that is, transferred to the gas-phase. An important example is electrospray-ionization mass spectrometry, which can provide a wide range of information about e. LÄS MER

5. 44. Targeting Biological Systems by Organic Synthesis Methods - Cancer Cells and Proteins

   Författare :Cecilia Winander; Lars Baltzer; Stefan Sjöberg; Jörgen Carlsson; Vladimir Tolmachev; Thomas Schrader; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; carborane; doxorubicin; 125I; molecular recognition; four-helix bundle; polypeptide conjugate; affinity; chitinase; acetylcholine esterase; Organisk kemi;

   Sammanfattning : This thesis describes the design and synthesis of molecules with potential roles in biomedicine, with an emphasis on molecular recognition in complex biological environments. The first chapter describes the synthesis and evaluation of compounds for use in nuclide therapy. LÄS MER

7. 45. Accuracy of protein synthesis and its tuning by mRNA modifications

   Författare :Gabriele Indrisiunaite; Måns Ehrenberg; Suparna Sanyal; Jaanus Remme; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Protein synthesis; Translation; Accuracy; Release factor; Termination; mRNA modifications; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : The ribosome is a large macromolecular complex that synthesizes all proteins in the cell in all kingdoms of life. Proteins perform many vital functions, ranging from catalysis of biochemical reactions to muscle movement. It is essential for cells and organisms that proteins are synthesized rapidly and accurately. LÄS MER