Sökning: "defined daily doses"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden defined daily doses.

  1. 1. On the clinical use of digitalis : with reference to its prescription, maintenance therapy, intoxication and the patient's knowledge

    Författare :Kurt Boman; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Digitalis; prescribing habits; dosages; defined daily doses; geriatric patients; maintenance therapy; withdrawal; intoxication; serum digitalis concentration; patient s knowledge;

    Sammanfattning : Digitalis in one of the most frequently prescribed drugs, especially to elderly people. The prescription of cardiac glucosides (1978) was studied by using statistics from Apoteksbolaget (the National Corpora­tion of Swedish Pharmacies). LÄS MER

  3. 2. The importance of the CYP2C19 polymorphism for disposition and effects of omeprazole treatment

    Författare :Mohamed Sagar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Omeprazole; CYP2C19; H. pylori; gastrin; intragastric pH; vitamin B12;

    Sammanfattning : CYP2C19, catalyzes the metabolism of omeprazole and several other drugs. About 3% of Caucasians are poor metabolizers (PM) of these drugs. The goal of this thesis was to evaluate the importance of CYP2C19 polymorphism for disposition and clinical effects of omeprazole treatment in healthy subjects and in patients with acid related disorders. LÄS MER

  4. 3. Benzodiazepine and opioid dependence. Clinical and meta-analytical studies

    Författare :Björn Axel Johansson; Kliniskt Centrum för Hälsofrämjande Vård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; clinical psychology; psychosomatics; Psychiatry; meta-analysis; opioid dependence; RCT; naltrexone; prescribed drugs; maintenance treatment; methadone; withdrawal symptoms; benzodiazepine dependence; DSM-IV; Psykiatri; klinisk psykologi; psykosomatik;

    Sammanfattning : The thesis contains 4 papers, two clinical studies and two meta-analyses. In the BZD taper study (Paper I) 21 BZD dependent (DSM-IV) patients were included for a 10-day inpatient detoxification. The average defined daily dose (DDD) was 4.7 doses. LÄS MER

  5. 4. A pharmacokinetic and pharmacodynamic study of an antiepileptic drug (lamotrigine) in young patients with drug-resistant generalized epilepsy

    Författare :Ann-Sofie Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :High-performance liquid chromatography; Antiepileptic drugs; Therapeutic drug monitoring; Lamotrigine; Carbamazepine; Epilepsy; Children; Lennox-Gastaut; Efficacy; CSF; [gamma]aminobuturic acid; Glutamate; Aspartate; Glycine; EEG;

    Sammanfattning : The purpose of the present study was to investigate the safety and efficacy of lamotrigine in young patients with drug-resistant generalised epilepsy. This group of patients is difficult to study due to a high seizure frequency, comorbidity and the frequent use of polytherapy. LÄS MER

  7. 5. Rectal cancer survivorship : work loss and long-term morbidity

    Författare :Lingjing Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the last few decades, due to early detection and advances in treatments, rectal cancer survival has been improved significantly. Meanwhile, rectal cancer survivors and health practitioners are facing more challenges arising from the disease, in terms of survivors’ longterm morbidity and work ability. LÄS MER