Sökning: "CYP2C19"

Visar resultat 1 - 5 av 35 avhandlingar innehållade ordet CYP2C19.

  1. 1. Pharmacogenetic analysis in sickness and in health - for better or for worse

    Författare :Mia Wadelius; Uppsala universitet; []
    Nyckelord :Medical sciences; Pharmacogenetics; NAT2; CYP2D6; CYP2C19; CYP17; GSTP1; sulphasalazine; agranulocytosis; prostate cancer; pregnancy; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : An individual's pharmacogenetic constitution may predict response to drugs, hormones and toxins, and might be a susceptibility factor for disease. Pharmacogenetic diversity is especially pronounced for drug metabolising enzymes. LÄS MER

  3. 2. Treatments and outcomes in bipolar disorder

    Författare :Erik Joas; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bipolar disorder; lithium; psychoeducation; CYP2C19; antidepressants; epidemiology; valproate; quetiapine; olanzapine; suicide;

    Sammanfattning : Bipolar disorder is defined by recurring mood episodes and patients have a markedly increased risk of suicide. Pharmacological and psychological treatments for bipolar disorder have proven efficacy in clinical trials yet the generalizability of current evidence to routine clinical practice is contested. LÄS MER

  4. 3. CYP2C19 catalyzed drug metabolism in different populations

    Författare :Karin Herrlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CYP2C19; drug metabolism; cytochrome P450; mephenytoin; omeprazole; proguanil chloroguanide ; citalopram; debrisoquine; CYP2D6; gene duplication; pharmacogenetics;

    Sammanfattning : Metabolism catalyzed by the cytochrome P450 enzyme CYP2C19 varies between individuals, who can be either efficient (EM) or poor metabolizers (PM). In this thesis the metabolism of four different CYP2C19 substrates (citalopram, mephenytoin, omeprazole, and proguanil) was investigated in vivo in Africans (Ethiopians an Tanzanians) an in Swedish is Caucasians. LÄS MER

  5. 4. CYP2C19 polymorphisms in drug metabolism and response

    Författare :Ming Chang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Individuals vary widely in their response to drug treatment. After receiving doses of a drug that are recommended based on a population average, some patients could have an insufficient response, whereas others may experience adverse effects. LÄS MER

  7. 5. Pharmacogenetics from a Forensic Perspective : CYP2D6 and CYP2C19 genotype distributions in autopsy cases

    Författare :Anna-Lena Zackrisson; Johan Ahlner; Bertil Lindblom; Magnus Ingelman-Sundberg; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : In Sweden about 550 individuals die every year due to drug intoxication. A challenge for the forensic toxicologist is to determine whether or not the analytical results can explain intoxication as a cause of death. The most common drugs found among intoxication cases are psychiatric drugs and analgesics. LÄS MER