Sökning: "Lamotrigine"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet Lamotrigine.

  1. 1. Bipolar disorders: Subtypes, treatments, and health inequalities

    Författare :Alina (Aikaterini) Karanti; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bipolar disorders; drug therapy; lithium; lamotrigine; quetiapine; mood stabilizers; antidepressants; electroconvulsive therapy; psychotherapy; psychoeducation; comorbidity; socioeconomic factors; healthcare disparity; gender; education;

    Sammanfattning : This thesis comprises five studies based on prospective, longitudinal data from the Swedish national quality register BipoläR. Study I examined the differences between bipolar subtype I and II with respect to clinical features, course of illness, comorbidity, and socioeconomic factors. LÄS MER

  3. 2. A pharmacokinetic and pharmacodynamic study of an antiepileptic drug (lamotrigine) in young patients with drug-resistant generalized epilepsy

    Författare :Ann-Sofie Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :High-performance liquid chromatography; Antiepileptic drugs; Therapeutic drug monitoring; Lamotrigine; Carbamazepine; Epilepsy; Children; Lennox-Gastaut; Efficacy; CSF; [gamma]aminobuturic acid; Glutamate; Aspartate; Glycine; EEG;

    Sammanfattning : The purpose of the present study was to investigate the safety and efficacy of lamotrigine in young patients with drug-resistant generalised epilepsy. This group of patients is difficult to study due to a high seizure frequency, comorbidity and the frequent use of polytherapy. LÄS MER

  4. 3. Metabolic drug interactions in man : methodological aspects on in vivo studies

    Författare :Ylva Böttiger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :drug interactions; drug metabolism; cytochrome P450; therapeutic drug monitoring; omeprazole; ketoconazole; tolterodine; ropivacaine; sirolimus; diltiazem; lamotrigine; humans;

    Sammanfattning : The aim of this thesis was to investigate methodological aspects on in vivo metabolic drug interaction studies in man. Five pharmacokinetic studies in healthy persons or patients are presented. Together, they represent a set of model studies to evaluate the occurrence of, and extent of metabolic drug interactions in vivo. LÄS MER

  5. 4. Drug-drug interactions : from knowledge base to clinical impact

    Författare :Marine Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Drug usage has increased steadily, and the more drugs used, the higher the risk for adverse effects or loss of effect due to drug-drug interactions. For drug prescribers it is difficult to know what drugs a patient is taking and whether they interact. LÄS MER

  7. 5. Acquired Epilepsy with a Focus on Stroke: Treatment and Prognosis

    Författare :David Larsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epilepsy; seizure; stroke; cerebrovascular disease; antiseizure medication;

    Sammanfattning : The relationship between epilepsy and stroke is complicated. While stroke is a major cause of epilepsy after middle age, there is also evidence that the risk of stroke is increased in persons with epilepsy. The overall aim of this dissertation is to elaborate on the prognosis and treatment of epilepsy in older adults and its association to stroke. LÄS MER