Sökning: "oligopeptide inhibitor"

Hittade 2 avhandlingar innehållade orden oligopeptide inhibitor.

1. 1. Activation and inhibition of diiron and iron-manganese ribonucleotide reductases

   Författare :Ana Popović-Bijelić; Astrid Gräslund; Anders Hofer; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; class Ic; C. trachomatis; cytotoxicity; KP772; lanthanum; manganese–iron cofactor; metal complex; oligopeptide inhibitor; ribonucleotide reductase; Triapine; tyrosyl radical; Biophysics; biofysik;

   Sammanfattning : Ribonucleotide reductase (RNR) catalyses the reduction of ribonucleotides to deoxyribonucleotides. In conventional class I RNRs the active site is located in the R1 subunit, and the R2 subunit contains a diiron cofactor and a stable tyrosyl radical essential for activity. LÄS MER

3. 2. Regulation of protein degradation by virus derived repeated amino acid sequences

   Författare :Ainars Leonchiks; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Epstein-Barr virus; glycine-alanine repeat; ubiquitin-proteasome pathway;

   Sammanfattning : The ubiquitin-proteasome pathway plays a central role in the controlled degradation of short-lived and regulatory proteins important m a variety of cellular processes, including antigen presentation and combating viral infections. The presentation of antigenic peptides derived from ubiquitin-proteasome dependent degradation of vital proteins to MHC class I restricted cytotoxic T cells is a central component of antiviral responses. LÄS MER