Sökning: "dNTP pools"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden dNTP pools.

1. 6. Mechanisms controlling DNA damage survival and mutation rates in budding yeast

   Författare :Jörgen Wiberg; Andrei Chabes; Per Sunnerhagen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dNTPs; ribonucleotide reductase; translesion synthesis; TLS polymerases; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : All living organisms are made of cells, within which genetic information is stored on long strands of deoxyribonucleic acid (DNA). The DNA encodes thousands of different genes and provides the blueprint for all of the structures and activities occurring within the cell. LÄS MER

3. 7. The Structure-Function Relationship and Evolution of Deoxyribonucleoside Kinases

   Författare :Zeeshan Mutahir; Molekylär cellbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : The synthesis of deoxyribonucleoside triphosphates (dNTPs), building blocks of DNA, can be achieved by two different pathways in the cell. One is called de novo synthesis and the other is known as salvage pathway. The de novo pathway involves synthesis of dNTPs by utilizing basic molecules like sugars, amino acids, CO2, NH3, etc. LÄS MER

4. 8. Transcriptional regulation of mouse ribonucleotide reductase

   Författare :Anna Elfving; Lars Thelander; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ribonucleotide reductase; promoters; cell cycle; transcriptional regulation; primer extension; protein purification; EMSA; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : All living organisms are made of cells and they store their hereditary information in the form of double stranded DNA. In all organisms DNA replication and repair is essential for cell division and cell survival. These processes require deoxyribonucleotides (dNTPs), the building blocks of DNA. LÄS MER

5. 9. Regulation of the Expression of Mouse Ribonucleotide Reductase Small Subunit at the Levels of Transcription and Protein Degradation

   Författare :Anna Lena Chabes; Lars Thelander; Ylva Engström; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; ribonucleotide reductase; transcription; protein degradation; cell cycle; Molekylärbiologi; Molecular biology; Molekylärbiologi; Medical Cell Biology; medicinsk cellbiologi;

   Sammanfattning : Deoxyribonucleic acid (DNA) carries all the genetic information of a cell. Ribonucleotide reductase (RNR) provides balanced pools of all four dNTPs, the building blocks of DNA. These building blocks are needed during DNA synthesis and repair. LÄS MER

7. 10. Mitochondrial dysfunction and treatment strategies

   Författare :Shuba Krishnan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The mitochondria are essential for cellular energy production and are involved in many processes in the cells. The mitochondria contain their own DNA (mtDNA) that is vital for oxidative phosphorylation since it encodes enzymes of the respiratory chain. LÄS MER