Sökning: "Ribonucleotide reductase"

Visar resultat 1 - 5 av 72 avhandlingar innehållade orden Ribonucleotide reductase.

  1. 1. Herpes simplex ribonucleotide reductase

    Författare :Rolf Ingemarson; []

    Sammanfattning : In all bacterial, plant and animal cells, as well as in many viruses, genetic information resides in DNA (deoxyribonucleic acid). Replication of DNA is essential for proliferation, and DNA-containing viruses (such as herpesviruses) must carry out this process within the mammalian cells they infect. LÄS MER

  2. 2. Ribonucleotide reductase and DNA damage

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Pelle Håkansson; Lars Thelander; Claes Gustafsson; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ribonucleotide reductase; DNA damage; dNTP pools; MEDICINE Morphology; cell biology; pathology Cell biology Medical cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi Medicinsk cellbiologi;

    Sammanfattning : A prerequisite for a multicellular organism to survive is the ability to correctly replicate and repair DNA while minimizing the number of heritable mutations. To achieve this, cells need a balanced supply of deoxyribonucleoside triphosphates (dNTPs), the precursors for DNA synthesis. LÄS MER

  3. 3. Allosteric Regulation and Radical Transfer in Ribonucleotide Reductase

    Detta är en avhandling från Stockholm : Institutionen för biokemi och biofysik

    Författare :Karl-Magnus Larsson; Pär Nordlund; Derek Logan; Roger Kornberg; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allosteric regulation; substrate specificity; ribonucleotide reductase; radical; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi;

    Sammanfattning : The stability of biological life over time requires that the integrity of the genetic material of an organism, the genome, be maintained as it is passed on from one generation to the next. All known cellular life has DNA-based genomes, which are duplicated before each cell division in a process called replication. LÄS MER

  4. 4. Class I Ribonucleotide Reductases overall activity regulation, oligomerization, and drug targeting

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Venkateswara Rao Jonna; Anders Hofer; Arne Holmgren; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductase; GEMMA; Allosteric regulation; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Ribonucleotide reductase (RNR) is a key enzyme in the de novo biosynthesis and homeostatic maintenance of all four DNA building blocks by being able to make deoxyribonucleotides from the corresponding ribonucleotides. It is important for the cell to control the production of a balanced supply of the dNTPs to minimize misincorporations in DNA. LÄS MER

  5. 5. Biophysical studies of ribonucleotide reductase

    Detta är en avhandling från Stockholm : Stockholm University

    Författare :Margareta Sahlin; [1986]

    Sammanfattning : Ribonucleotide reductase (EC 1.17.4) catalyses the enzymatic reduction of ribonucleotides to their corresponding deoxyribo- nucleotides, the monomeric precursors for the DNA synthesis in all living cells. All ribonucleotide reductases so far Isolated from different species have been found to contain metal ions, either iron, cobolt or manganese. LÄS MER