Sökning: "translesion synthesis"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden translesion synthesis.

  1. 1. Structure of eukaryotic DNA polymerase epsilon and lesion bypass capability

    Författare :Nasim Sabouri; Erik Johansson; Lars Thelander; Ola Hammarsten; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA polymerase epsilon; DNA replication; Okazaki fragment; Translesion synthesis; DNA lesion; dNTP; Biochemistry; Biokemi;

    Sammanfattning : To transfer the information in the genome from mother cell to daughter cell, the DNA replication must be carried out only once and with very high fidelity prior to every cell division. In yeast there are several different DNA polymerases involved in DNA replication and/or DNA repair. LÄS MER

  3. 2. Mechanisms controlling DNA damage survival and mutation rates in budding yeast

    Författare :Jörgen Wiberg; Andrei Chabes; Per Sunnerhagen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dNTPs; ribonucleotide reductase; translesion synthesis; TLS polymerases; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : All living organisms are made of cells, within which genetic information is stored on long strands of deoxyribonucleic acid (DNA). The DNA encodes thousands of different genes and provides the blueprint for all of the structures and activities occurring within the cell. LÄS MER

  4. 3. The consequences of DNA lesions for mitochondrial DNA maintenance

    Författare :Josefin M. E. Forslund; Sjoerd Wanrooij; Nasim Sabouri; Erik Johansson; Claes Gustafsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mitochondrial DNA; DNA replication; DNA lesions; DNA polymerase γ; ribonucleotide incorporation; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Eukaryotic cells have their own energy-producing organelles called mitochondria. The energy is stored in the adenosine triphosphate (ATP) molecule and is produced via the oxidative phosphorylation process inside the mitochondria. Thirteen of the essential proteins required for this process are encoded on the mitochondrial DNA (mtDNA). LÄS MER

  5. 4. Factors Influencing the Yield of Mutations Induced by Polycyclic Aromatic Hydrocarbons in Mammalian Cells

    Författare :Anne Lagerqvist; Dag Jenssen; Klaus Erixon; Fredrik Johansson; Hanspeter Naegeli; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi; toxikologisk genetik; Toxicological Genetics;

    Sammanfattning : Environmental contaminants are ubiquitously present in the urban environment, this has the implication that humans are exposed to toxic and carcinogenic chemicals. Polycyclic aromatic hydrocarbons (PAH) are one type of environmental contaminants, which are produced by combustion of organic compounds. LÄS MER

  7. 5. Interstrand Crosslinks - Induction and repair

    Författare :Daniel Vare; Dag Jenssen; Klaus Erixon; Fredrik Johansson; Marcel Tijsterman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ICL; DNA repair; interstrand crosslink; psoralen; molekylärgenetik; Molecular Genetics;

    Sammanfattning : DNA crosslinking agents exhibit a variety of DNA lesions, such as monoadducts, DNA-DNA interstrand or intrastrand crosslinks or DNA-protein crosslinks. Agents that produce interstrand crosslinks (ICLs) exist naturally and are widely used in chemotherapy. Therefore, it is important to understand how the lesions induced by these agents are repaired. LÄS MER