Sökning: "dNTPs"

Visar resultat 1 - 5 av 22 avhandlingar innehållade ordet dNTPs.

  1. 1. dNTPs : the alphabet of life

    Författare :Dinesh Kumar; Andrei Chabes; Britt-Marie Sjöberg; Umeå universitet; []
    Nyckelord :ribonucleotide reductase; dNTP pools; s-phase checkpoint; mutagenesis; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : From microscopic bacteria to the giant whale, every single living organism on Earth uses the same language of life: DNA. Deoxyribonucleoside triphosphates––dNTPs (dATP, dTTP, dGTP, and dCTP)––are the building blocks of DNA and are therefore the “alphabet of life”. LÄS MER

  3. 2. Mechanisms controlling DNA damage survival and mutation rates in budding yeast

    Författare :Jörgen Wiberg; Andrei Chabes; Per Sunnerhagen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dNTPs; ribonucleotide reductase; translesion synthesis; TLS polymerases; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : All living organisms are made of cells, within which genetic information is stored on long strands of deoxyribonucleic acid (DNA). The DNA encodes thousands of different genes and provides the blueprint for all of the structures and activities occurring within the cell. LÄS MER

  4. 3. The Structure-Function Relationship and Evolution of Deoxyribonucleoside Kinases

    Författare :Zeeshan Mutahir; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The synthesis of deoxyribonucleoside triphosphates (dNTPs), building blocks of DNA, can be achieved by two different pathways in the cell. One is called de novo synthesis and the other is known as salvage pathway. The de novo pathway involves synthesis of dNTPs by utilizing basic molecules like sugars, amino acids, CO2, NH3, etc. LÄS MER

  5. 4. Pathology of dNTP dysregulation

    Författare :Phong Tran; Andrei Chabes; Erik Johansson; Ola Hammarsten; Umeå universitet; []
    Nyckelord :dNTP metabolism; DNA replication; mutation rate; cancer; heart development; RNR; SAMHD1; Rrm1; Samhd1; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Deoxyribonucleoside triphosphates (dNTPs) are precursors for DNA replication and repair. Mammalian cells have two distinct biosynthesis pathways to supply dNTPs: de novo and salvage pathways. LÄS MER

  7. 5. Transcriptional regulation of mouse ribonucleotide reductase

    Författare :Anna Elfving; Lars Thelander; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ribonucleotide reductase; promoters; cell cycle; transcriptional regulation; primer extension; protein purification; EMSA; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : All living organisms are made of cells and they store their hereditary information in the form of double stranded DNA. In all organisms DNA replication and repair is essential for cell division and cell survival. These processes require deoxyribonucleotides (dNTPs), the building blocks of DNA. LÄS MER