Sökning: "David Teplow"

Hittade 1 avhandling innehållade orden David Teplow.

1. 1. Aβ Conformation Dependent Antibodies and Alzheimer's Disease

   Författare :Dag Sehlin; Lars Lannfelt; Frida Ekholm Pettersson; David Teplow; Uppsala universitet; []
   Nyckelord :Alzheimer s disease; amyloid-beta; protofibrils; conformation; monoclonal antibody; ELISA; MEDICINE; MEDICIN; Geriatrics; Geriatrik;

   Sammanfattning : Soluble intermediates of the amyloid-β (Aβ) aggregation process are suggested to play a central role in the pathogenesis of Alzheimer’s disease (AD) by causing synaptic dysfunction and neuronal loss. In this thesis, soluble Aβ aggregates have been studied with a particular focus on the Aβ protofibril, which has served as the antigen for developing conformation dependent monoclonal antibodies. LÄS MER