Sökning: "brain-derived neurotrophic factor i"
Visar resultat 1 - 5 av 31 avhandlingar innehållade orden brain-derived neurotrophic factor i.
1. Brain-derived neurotrophic factor in cerebral ischemia: a quantitative study on surviving and newly formed neurons
Sammanfattning : This study explores the role of brain-derived neurotrophic factor (BDNF) for neuronal vulnerability and neurogenesis following cerebral ischemia in the rat. Cerebral ischemia results in selective neuronal cell loss in specific brain regions. We here demonstrate the rank order of vulnerability in two regions affected by global forebrain ischemia, i. LÄS MER
2. Role of Endogenous BDNF and NT3 for Synaptic Transmission and Plasticity in the Dentate gyrus
Sammanfattning : The neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modulate synaptic transmission and synaptic plasticity in the adult mammalian brain. Recent data suggest that neurotrophins might be mediators of activity-dependent synaptic plasticity. LÄS MER
3. Stroke and Functional Recovery - An experimental study on environmental influence and gene expression after cortical infarcts in the rat
Sammanfattning : Abstract Stroke is the third leading cause of death in the western world, and the number one cause of disability. 85% of all strokes are ischemic. Most stroke survivors will experience recovery of function. The mechanisms behind this improvement are partly unknown, but may involve elements of both compensation and restoration. LÄS MER
4. Neuropeptides and neurotrophins in arthritis : studies on the human and mouse knee joint
Sammanfattning : Neuropeptides, such as substance P (SP) and bombesin/gastrin-releasing peptide (BN/GRP), and neurotrophins are involved in neuro-immunomodulatory processes and have marked trophic, growth-promoting and inflammation-modulating properties. The impact of these modulators in rheumatoid arthritis (RA) is, however, unclear. LÄS MER
5. Neurotrophic factors and their receptors structure-function relationships and signalling mechanisms
Sammanfattning : Background: The development, survival and maintenance of the vertebrate nervous system requires the continuous supply of a set of polypeptides termed neurotrophic factors. Among these, the neurotrophins (NTs) and members of the transforming growth factor-B (TGF-B) superfamily have raised substantial hopes for future clinical applications. LÄS MER