Sökning: "TFR1"

Hittade 4 avhandlingar innehållade ordet TFR1.

  1. 1. CRISPR Screens Identify Candidate Therapeutic Targets in Leukemia

    Författare :Maria Rodriguez Zabala; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; CRISPR screen; leukemia stem cell; cell surface receptor; metabolism; immunotherapy; CXCR4; GLUT1; TFR1; H2-K1;

    Sammanfattning : Acute myeloid leukemia (AML) is a complex hematological malignancy marked by proliferation of immature myeloid cells with a dismal 5-year survival. A major challenge is the persistence of leukemia stem cells (LSCs) after standard treatment, leading to relapse. LÄS MER

  3. 2. Clinical and experimental studies on HFE and other genes involved in iron homeostasis

    Författare :Petra Holmström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hereditary hemochromatosis; iron overload; HFE gene mutations; porphyria cutanea tarda; HFE gene; iron metabolism-related genes; iron homeostasis; liver; inflammation; and hepatocellular carcinoma;

    Sammanfattning : In this thesis, the clinical significance of HFE mutations was further investigated, and the molecular mechanisms underlying the disturbed iron homeostasis during hemochromatosis, inflammation and hepatocellular carcinoma were studied in experimental models. Hereditary hemochromatosis (HH) is a prevalent autosomal recessive iron overload disorder caused by increased intestinal absorption and deposition of iron in vital organs, leading to organ damage. LÄS MER

  4. 3. Studies of proteins in heme and iron metabolism

    Författare :Vijole Dzikaite; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Iron; Heme; IRE IRP; Liver; eALAS; HFE;

    Sammanfattning : One aim of the study was to investigate the regulation of the murine erythroid isoform of aminolevulinate synthase (eALAS) protein involved in heme synthesis. Another aim was to characterize the structure of the rat hemochromatosis gene (HFE) gene and its expression in conjunction with other genes involved in the regulation of iron homeostasis during inflammation and iron overload in the rat liver. LÄS MER

  5. 4. Experimental and clinical studies on liver regeneration and hepatocellular carcinoma : roles of redox proteins, iron homeostasis and multikinase inhibition

    Författare :Annelie Mollbrink; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Compensatory liver regeneration is triggered by chronic liver injury or surgery and is crucial to maintain tissue homeostasis. The underlying mechanisms which include a whole battery of complex signaling events have been thoroughly studied for decades. LÄS MER