Sökning: "dynorphin A"

Visar resultat 1 - 5 av 38 avhandlingar innehållade orden dynorphin A.

  1. 1. The opioid peptide dynorphin A : Biophysical studies of peptide–receptor and peptide–membrane interactions

    Författare :Johannes Björnerås; Lena Mäler; Astrid Gräslund; Scott Prosser; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; dynorphin A; opioid receptor; neuropeptide; bicelles; NMR; diffusion; decomposition; Biophysics; biofysik;

    Sammanfattning : The work presented in this thesis concerns the opioid peptide dynorphin A (DynA). DynA functions primarily as a neurotransmitter and belongs to the family of typical opioid peptides. These peptides are a part of the opioid system, together with the opioid receptors, a family of GPCR membrane proteins. LÄS MER

  2. 2. Involvement of the Opioid System in High Alcohol Consumption : Environmental and Genetic Influences

    Författare :Karolina Ploj; Jörgen A Engel; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Opioids; ethanol; stress; maternal separation; neonatal handling; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Sammanfattning : It is well accepted that both inherent and environmental factors influence the pathogenesis of alcohol dependence. This thesis investigates the role of the opioid system in the initiation and maintenance of high ethanol intake. LÄS MER

  3. 3. Dynorphin A – Interactions with receptors and the membrane bilayer

    Författare :Johannes Björnerås; Lena Mäler; Astrid Gräslund; Göran Widmalm; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biophysics; biofysik; Biochemistry; biokemi;

    Sammanfattning : The work presented in this thesis concerns the dynorphin neuropeptides, and dynorphin A (DynA) in particular. DynA belongs to the wider class of typical opioid peptides that, together with the opioid receptors, a four-membered family of GPCR membrane proteins, form the opioid system. LÄS MER

  4. 4. Biophysical studies of peptides with functions in biotechnology and biology

    Författare :Fatemeh Madani; Astrid Gräslund; Steven F. Dowdy; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Genetic fluorescence label; Biarsenical tetracysteine motif; Cell-penetrating peptides; Large unilamellar vesicles; Pyrenebutyrate; Endosomal escape; Membrane perturbation; Bacteriorhodopsin; Dynorphin; Biophysics; biofysik;

    Sammanfattning : My thesis concerns spectroscopic studies (NMR, CD and fluorescence) of peptides with functions in biotechnology and biology, and their interactions with a model membrane (large unilamellar phospholipid vesicles).The resorufin-based arsenical hairpin binder (ReAsH) bound to a short peptide is a useful fluorescent tag for genetic labeling of proteins in living cells. LÄS MER

  5. 5. The Impact of Nandrolone Decanoate on Neuropeptidergic Mechanisms Related to Cognition, Aggression, Reward and Dependence

    Författare :Kristina Magnusson; Fred Nyberg; Mathias Hallberg; Santi Mario Spampinato; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anabolic androgenic steroids; Nandrolone decanoate; Substance P; Dynorphin A; KOP receptor; Prodynorphin; Radioimmunoassay; Autoradiography; Morris water maze; PCR; Central nervous system; Biological research on drug dependence; Biologisk beroendeforskning; Biological Research on Drug Dependence; Biologisk beroendeforskning;

    Sammanfattning : The abuse of anabolic androgenic steroids (AAS) is becoming increasingly common and may result in a range of physiological as well as psychological effects such as altered behavior in terms of increased aggression, cognitive dysfunction and addictive behavior. AAS comprise testosterone and its derivatives, of which nandrolone is one of the more common. LÄS MER