Sökning: "benzoic acid"

Visar resultat 16 - 20 av 25 avhandlingar innehållade orden benzoic acid.

1. 16. Exploring molecular interactions between polypeptide conjugates and protein targets : Manipulating affinity by chemical modifications

   Författare :Aleksandra Balliu; Lars Baltzer; Oliver Seitz; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; polypeptide conjugates; protein targets; molecular recognition; affinity enhancement; conjugation;

   Sammanfattning : In this thesis molecular interactions between polypeptide conjugates and protein targets were investigated. Polypeptides were derivatized with small organic molecules, peptides and oligonucleotides. New strategies were developed with the aim to increase affinities for proteins of biological interest. LÄS MER

3. 17. Metallacyclic Phosphine Complexes and Intramolecular Csp3-H Bond Activation -Synthesis, Characterisation and Catalytic Application

   Författare :Sven Sjövall; Kemiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; catalysis; Heck; diphosphite; diphosphine; phosphine; cyclometallation; C-C activation; C-O activation; C-H activation; palladium; rhodium; iridium; Inorganic chemistry; Oorganisk kemi;

   Sammanfattning : The work presented in this thesis deals with metallacyclic late transition metal complexes, obtained by intramolecular Csp3-H activation, and the application of such compounds in catalysis. The new hemilabile P,O phosphines N-methyl-N-propionyl-2-(diphenylphosphino)benzylamine (DPPAM), o-(diphenylphosphino)benzoic acid ethyl ester (DPPES), o-(diphenylphosphino)benzoic acid methyl ether (DPPET) and ±-1-(2- diphenylphosphino)phenylethyl propionate (±-DPPMES) and the symmetrical diphosphorus donor ligands cis-1,3-bis[(diphenylphosphino)methyl]-cyclohexane (DPCY), cis-1,3-bis[(di-tertbutylphosphino)methyl]cyclohexane (DTBCY) and cis-1,3-bis[(di-isopropylphosphino)methyl]cyclohexane (DIPCY) have been synthesised, allowing the preparation of a range of new metallacyclic rhodium(III), iridium(III) and palladium(II) complexes. LÄS MER

4. 18. Probing the Alpha Class Glutathione Transferase Structure. Combinatorial Subunit Studies and Rational Redesign

   Författare :Ann Gustafsson; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Glutathione transferases; rational redesign; enzyme; catalysis; Biokemi; Biochemistry; Biokemi; Molecular Biotechnology; molekylär bioteknik avd f jonfysik ;

   Sammanfattning : The present work concerns two Alpha class enzymes, GST A1-1 and GST A4-4, of the glutathione transferase (GST) family, which are detoxication enzymes catalyzing the conjugation of the tripeptide glutathione with various electrophiles. The GST A1-1 structure was explored for protein engineering purposes and tailored for increased activity toward alkenals. LÄS MER

5. 19. Catalysis and Site-Specific Modification of Glutathione Transferases Enabled by Rational Design

   Författare :Sofia Håkansson Hederos; Lars Baltzer; Kerstin Broo; Linköpings universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Catalysis; Glutathione Transferases; Rational design; Protein design; Site-specific modification; thiolester hydrolysis; Enzyme engineering; Enzymteknik;

   Sammanfattning : This thesis describes the rational design of a novel enzyme, a thiolester hydrolase, derived from human glutathione transferase (GST) A1-1 by the introduction of a single histidine residue. The first section of the thesis describes the design and the determination of the reaction mechanism. LÄS MER

7. 20. Novel electrode and photoelectrode materials for hydrogen production based on molecular catalysts

   Författare :Andrew J. Bagnall; Leif Hammarström; Vincent Artero; Sascha Ott; Alexander Cowan; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; electrochemical mechanism; hydrogen; artificial photosynthesis; molecular catalyst; hydrogen evolution; cobalt; Kemi; Chemistry;

   Sammanfattning : The PhD project focussed on the application of a cobalt tetraazamacrocyclic complex, in the literature commonly referred to as [Co(CR)Cl2]+ as a molecular catalyst for the hydrogen evolution reaction (HER). This was within the broader scope of the EU MSCA H2020 ITN ‘eSCALED’ project, which primarily aimed to create artificial leaf devices for the storage of solar energy in chemical fuels and, as part of this, sought the development of novel bio-inspired and scalable materials. LÄS MER