Sökning: "secondary nucleation"

Visar resultat 1 - 5 av 36 avhandlingar innehållade orden secondary nucleation.

  1. 1. Secondary Nucleation in Amyloid Formation

    Författare :Mattias Törnquist; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease; amyloid; Ab42; aggregation mechanism; aggregation kinetics; secondary nucleation; Protein misfolding;

    Sammanfattning : Research into Alzheimer's disease is still hampered by a lack of fundamental understanding of the underlying mechanisms. While the aggregation of the amyloid β peptide (Aβ) into amyloid fibrils is highly implicated as a key factor in the disease, the molecular nature of its involvement has proven complex and elusive. LÄS MER

  3. 2. Understanding secondary nucleation of the amyloid β peptide

    Författare :Dev Thacker; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease AD ; A beta 1-42; Amyloid aggregation; secondary nucleation;

    Sammanfattning : Alzheimer’s Disease (AD) is a devastating neurodegenerative disease associated with massive neuronal cell death during its pathology. The involvement of the amyloid β 42 (Aβ42) peptideand its role in neurotoxicity is now well established. LÄS MER

  4. 3. Amyloid beta aggregation kinetics : The role of intrinsic and extrinsic factors

    Författare :Xiaoting Yang; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease; Abeta; aggregation; kinetics; secondary nucleation;

    Sammanfattning : Cerebral senile plaque is one of the main pathologies of Alzheimer's disease (AD). The amyloid cascade hypothesis suggests that the aggregation of amyloid beta (Abeta) peptide is involved in the pathogenesis of AD, which is supported by the fact that Abeta overexpression or production of more aggregation-prone variants lead to early-onset dementia. LÄS MER

  5. 4. Fine Scale Microstructures of Josephson Junctions in YBa2Cu3O7-δ Thin Film Structures

    Författare :Marica Gustafsson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; superconductors; thin film evolution; microstructure; nucleation; Josephson junctions; multilayer; YBa2Cu3O7-delta; transmission electron microscopy;

    Sammanfattning : This work concerns the microstructure of YBa2Cu3O7-.delta. (YBCO) and other related thin films in multilayer structures, studied by mainly transmission electron microscopy (TEM). LÄS MER

  7. 5. Improved Cloud Parameterization in Global Climate Model : Aerosol effects and secondary ice production mechanisms

    Författare :Arti Jadav; MERGE: ModElling the Regional and Global Earth system; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cloud; Coud parameterization; Primary ice mechanisms; Secondary ice production; Global climate model;

    Sammanfattning : The response of clouds to the changes in climate is uncertain, and the representation of the cloud-climate feedback is a key challenge in the global circulation models (GCM) for future climate projections. Factors contributing to this uncertainty include processes that involve particles of various sizes and phases, as well as the interactions between these particles and the surrounding atmosphere. LÄS MER