Sökning: "amyloid β-peptide"
Visar resultat 11 - 15 av 37 avhandlingar innehållade orden amyloid β-peptide.
11. Identification and Characterization of Peptides and Proteins using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
Sammanfattning : Mass spectrometry has in recent years been established as the standard method for protein identification and characterization in proteomics with excellent intrinsic sensitivity and specificity. Fourier transform ion cyclotron resonance is the mass spectrometric technique that provides the highest resolving power and mass accuracy, increasing the amount of information that can be obtained from complex samples. LÄS MER
12. Role of pro-inflammatory S100A9 protein in amyloid-neuroinflammatory cascade in Alzheimer’s disease and traumatic brain injury
Sammanfattning : Background Traumatic brain injury (TBI) is a complex disease with a spectrum of symptoms and disabilities. Over the past decade TBI has become the focus of research due to growing epidemiological and clinical evidences that TBI incidences are strong risk factors for Alzheimer’s disease (AD). LÄS MER
13. Polysaccharides in Alzheimer's disease and inflammation-associated amyloidosis
Sammanfattning : Amyloidosis is a term for diseases that share a common feature: the extracellular deposition of amyloid fibrils, that consist of a single protein prone to aggregate. Polysaccharides (glycos-aminoglycans), especially heparan sulfate, are significant components of all types of amyloid deposits. LÄS MER
14. Protein misfolding and amyloid formation : strategies for prevention
Sammanfattning : Most proteins need to adopt a three-dimensional structure in order to function properly. Misfolding, or inability of proteins to fold, is associated with a number of diseases. In a subset of these disorders, the misfolded protein or peptide selfassembles into stable, β-sheet rich structures known as amyloid fibrils. LÄS MER
15. BRICHOS interactions with amyloid proteins and implications for Alzheimer disease
Sammanfattning : To date, about 30 diseases, in which amyloid fibrils form extracellular deposits, have been identified in humans. It is not known if the fibrils have a function, like storage of misfolded proteins, or if they just reflect failure of the cell to manage misfolded proteins. LÄS MER