Sökning: "amyloid β-peptide"

Visar resultat 16 - 20 av 37 avhandlingar innehållade orden amyloid β-peptide.

  1. 16. To Fold or To Fibrillate? Serendipity in Stability Studies

    Författare :Olga Szczepankiewicz; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein stability; protein reconstitution; protein aggregation; Monellin; PGB1; Split-GFP; Amyloid beta;

    Sammanfattning : Proteins are complex structures and years of research have been spent on attempts to understand their complexity. The non-covalent interactions involved in protein folding are: hydrophobic effect, electrostatic interactions, van der Waals interactions and hydrogen bonding. LÄS MER

  3. 17. Enhancing the therapeutic effect of biological drugs with protein engineering : Focusing on pre-clinical Alzheimer’s disease therapy

    Författare :Fadi Rofo; Greta Hultqvist; Stina Syvänen; Sara Mangsbo; Joy Zuchero; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; amyloid-beta; blood-brain barrier; transferrin receptor; protein-drugs; multivalent-bispecific antibodies;

    Sammanfattning : Aggregation of the amyloid-β peptide (Aβ) is one of the main pathological hallmarks in Alzheimer’s disease (AD). The soluble Aβ aggregates (oligomers and protofibrils) have shown to be the most harmful species. Hence, targeting these aggregates can be of therapeutic potential. LÄS MER

  4. 18. BRICHOS - a Novel Anti-Amyloid Chaperone : studies on pro-surfactant protein C

    Författare :Hanna Willander; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Lung surfactant protein C (SP-C) is a 35-residue, transmembrane (TM) peptide that is extremely hydrophobic and lacks known homologous proteins. Due to a high content in Val residues in the α-helical TM part, SP-C can spontaneously convert into β-sheet aggregates. LÄS MER

  5. 19. Mechanistic and morphological studies of Aβ amyloid formation using surface plasmon resonance

    Författare :Md Tohidul Islam; Anders Olofsson; Ludmilla Morozova-Roche; Vytautas Smirnovas; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; medicinal chemistry; läkemedelskemi; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia and apart from the individual suffering AD also causes a large economic burden for society. AD is associated with progressive neurodegeneration and atrophy of the brain. LÄS MER

  7. 20. Studies of amyloid toxicity in Drosophila models and effects of the BRICHOS domain

    Författare :Erik Hermansson Wik; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Amyloid diseases involve specific protein misfolding events and formation of fibrillar deposits. The symptoms of these diseases are broad and dependent on site of accumulation, with different amyloid proteins depositing in specific tissues or systematically. LÄS MER