Sökning: "amyloid β-peptide"
Visar resultat 21 - 25 av 37 avhandlingar innehållade orden amyloid β-peptide.
21. Losing connections in Alzheimer disease : the amyloid precursor protein processing machinery at the synapse
Sammanfattning : Synaptic degeneration is one of the earliest characteristics of Alzheimer disease (AD). The amyloid β-peptide (Aβ) plays a critical role in the pathology of AD and therefore thorough understanding of its production and functions is of outmost importance. LÄS MER
22. N-Unsubstituted Glucosamine Residues in Heparan Sulfate and Their Potential Relation to Alzheimer's Disease
Sammanfattning : Heparan sulfate (HS) is a linear polysaccharide, located on the surface and in the extracellular matrix of most cells, that regulates functions of numerous proteins. HS-protein interaction is mainly mediated by sulfate groups found in N-sulfated (NS) regions of the HS, but may also involve rare HS substituents such as N-unsubstituted glucosamine (GlcNH2) residues. LÄS MER
23. Intracellular dynamics of Alzheimer disease-related proteins
Sammanfattning : Alzheimer’s disease is a devastating neurodegenerative disorder characterized by accumulation of amyloid-β peptide and formation of amyloid plaques and aggregates of hyperphosphorylated tau protein forming neurofibrillary tangles. The amyloid-β peptide is generated through sequential processing of the amyloid precursor protein (APP) by β- and γ-secretase. LÄS MER
24. Understanding the dual nature of lysozyme: part villain – part hero : A Drosophila melanogaster model of lysozyme amyloidosis
Sammanfattning : Amyloid proteins are a distinct class of proteins that can misfold into β-sheet rich structures that later mature to form the characteristic species known as amyloid fibrils, and accumulate in tissues in the human body. The misfolding event is often caused by mutations (or outer factors such as changes in pH) that destabilize the native protein structure. LÄS MER
25. Alzheimer disease : subcellular Aβ mechanisms and treatment strategies
Sammanfattning : The amyloid β-peptide (Aβ) is the key molecule in the pathogenesis of Alzheimer disease (AD), but the mechanisms of its toxicity are still largely unknown. This thesis includes studies aimed at studying Aβ induced mechanisms in neurons at the subcellular level and explore effective AD treatment strategies. LÄS MER