Sökning: "amino acid derivatives"

Visar resultat 1 - 5 av 58 avhandlingar innehållade orden amino acid derivatives.

1. 1. Amino acid-catalyzed synthesis of amino acid derivatives : Application and semi-synthesis of Paclitaxel, Docetaxel and their derivatives

   Författare :Pawel Dziedzic; Armando Córdova; Stephen Hanessian; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Organocatlysis; amino acids; syntesis; Taxol and Taxotere derivatives; Chemistry; Kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis deals with different applications of organocatalysis, where amino acid derivatives and small peptides are applied as catalysts. First, the development of environmentally friendly aldol reactions, carried out in aqueous media is illustrated. The corresponding β-hydroxy ketones are formed with ee´s up to 99%. LÄS MER

3. 2. Development of New Methodology in Organic Synthesis: Lewis Acid-Mediated Rearrangements of Ammonium Ylides and Addition of 1, 3-bis(silyl) propenes to Aldehydes

   Författare :Pavel Tuzina; Peter Somfai; Ari Koskinen; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; asymmetric; amino acid; ammonium ylide; Lewis acid; microwave irradiation; Organic synthesis; Organisk syntes;

   Sammanfattning : This thesis deals with the development of new methodologies in organicsynthesis. The main focus is on the development of Lewis acid-mediated [1,2]-rearrangements of ammonium ylides and the novel addition of 1,3-bis(silyl)propenes to carbonyl compounds. LÄS MER

4. 3. Asymmetric Transfer Hydrogenation of Aromatic Ketones : Catalyst Development and Mechanistic Studies

   Författare :Sofia Nordin; Torbjörn Frejd; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; transfer hydrogenation; aza-norbornyl structure; amino acid derivatives; amino alcohols; ruthenium; concerted mechanism; asymmetric catalysis.; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis describes the development and evaluation of new chiral Ru(arene)(amino alcohol) catalysts for the transfer hydrogenation of aromatic ketones using isopropanol as the hydrogen source. Two mechanistic studies of the Ru(arene)(amino alcohol) catalyzed transfer hydrogenation of acetophenone were also conducted. The Ru(arene)[(1S,3R,4R)-3. LÄS MER

5. 4. Synthesis of heterocycles from anthranilic acid and its derivatives

   Författare :Per Wiklund; Jan Bergman; Norbert de Kimpe; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Anthranilic acid; synthesis; heterocycles; benzodiazepines; HNO nitrosyl ;

   Sammanfattning : Anthranilic acid (2-aminobenzoic acid, Aa) is the biochemical precursor to the amino acid tryptophan, as well as a catabolic product of tryptophan in animals. It is also integrated into many alkaloids isolated from plants. Aa is produced industrially for production of dyestuffs and pharmaceuticals. LÄS MER

7. 5. Synthesis of Non-Natural Aromatic Amino Acids Derivatives Solvent-free reactions-Versatile building blocks-Galectin inhibitors

   Författare :Erik Tullberg; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; Naturvetenskap; Natural science; Multivalent galectin inhibitors; Multifunctional molecules; Amino Acids; Solvent-free reactions;

   Sammanfattning : This thesis deals with three topics concerning the synthesis of non-natural also known as unnatural amino acid derivatives. In the first, solvent-free reaction conditions for the Heck reaction were developed that were superior to previous conditions because the reaction time could be reduced and the work-up procedure simplified. LÄS MER