Sökning: "affibody"

Visar resultat 16 - 20 av 90 avhandlingar innehållade ordet affibody.

  1. 16. Generation and characterization of Affibody molecules targeting HER3

    Författare :Magdalena Malm; Stefan Ståhl; Jennifer Cochran; KTH; []
    Nyckelord :Affibody molecules; epidermal growth factor receptors; HER3; ErbB3; combinatorial protein engineering; combinatorial library; staphylococcal surface display;

    Sammanfattning : In the field of oncology, the ability to target specific tumor cells using highly selective targeting molecules is an attractive and emerging concept. In this context, the epidermal growth factor receptor HER3 has proven central to the biology behind many different human cancers and inhibition of the signaling mediated by this receptor could provide antitumoral effects. LÄS MER

  3. 17. Radiolabelled affibody molecules for imaging EGFR expression in tumours

    Författare :Maryam Oroujeni; Vladimir Tolmachev; Martin Behe; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affibody molecules; ZEGFR:2377; radionuclide molecular imaging; PET; SPECT; labelling chemistry.;

    Sammanfattning : Affibody molecules are promising scaffold-based targeting proteins for radionuclide imaging and cancer therapy. This thesis is based on 5 original research articles (Papers I-V), with the primary focus being placed on the optimization of molecular design of EGFR-binding affibody variants for high contrast imaging of epidermal growth factor receptor (EGFR) expression in tumours. LÄS MER

  4. 18. Affibody Molecules for HER3-targeted Theranostics of Malignant Tumours

    Författare :Maria Rosestedt; Anna Orlova; Vladimir Tolmachev; Olof Eriksson; Sten Nilsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affibody molecules; theranostics; HER3; molecular imaging;

    Sammanfattning : The HER3 receptor plays a strong role in disease progression and resistance to therapies in several cancer types. Due to its endogenous expression and low overexpression in malignant tumours, it is a particularly challenging target. LÄS MER

  5. 19. Investigations of chemical and enzymatic functionalization of affinity proteins

    Författare :Anders Myrhammar; Amelie Eriksson Karlström; Per-Åke Nygren; Christian Heinis; KTH; []
    Nyckelord :Affinity protein; affibody; conjugation; solid phase peptide synthesis; proteolytic stability; peptide nucleic acid PNA .; Bioteknologi; Biotechnology;

    Sammanfattning : AbstractAffinity proteins are important reagents in research, diagnostics and therapeutic settings. The focus of this thesis has been on investigating different chemical and enzymatic strategies for engineering of affinity proteins to generate affinity reagents with improved or changed functionality. LÄS MER

  7. 20. Combinatorial Protein Engineering Of Affibody Molecules Using E. Coli Display And Rational Design Of Affibody-Based Tracers For Medical Imaging

    Författare :Ken G. Andersson; John Löfblom; Stefan Ståhl; Harald Kolmar; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; directed evolution; microbial display; E. coli; Affibody molecule; autotransporter; medical imaging; HER receptor family; Sortase A; Bioteknologi; Biotechnology;

    Sammanfattning : Directed evolution is today an established strategy for generation of new affinity proteins. This thesis describes the development of a cell-display method using Escherichia coli for directed evolution of Affibody molecules. LÄS MER