Sökning: "affibody"

Visar resultat 11 - 15 av 89 avhandlingar innehållade ordet affibody.

  1. 11. Affibody molecules targeting the epidermal growth factor receptor for tumor imaging applications

    Författare :Mikaela Friedman; Stefan Ståhl; Fredrik Nilsson; James S. Huston; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; affinity maturation; phage display selection; EGFR; molecular imaging; protein engineering; tumor targeting; Bioengineering; Bioteknik;

    Sammanfattning : Tumor targeting and molecular imaging of protein markers specific for or overexpressed in tumors can add useful information in deciding upon treatment and assessing the response to treatment for a cancer patient. The epidermal growth factor receptor (EGFR) is one such tumor-associated receptor, which expression is abnormal or upregulated in various cancers and associated with a poor patient prognosis. LÄS MER

  3. 12. Tumour Targeting using Radiolabelled Affibody Molecules : Influence of Labelling Chemistry

    Författare :Mohamed Altai; Vladimir Tolmachev; Jacques Barbet; Uppsala universitet; []
    Nyckelord :HER2; Affibody molecule; Radionuclide molecular maging; Targeted radionuclide therapy; Labeling chemistry;

    Sammanfattning : Affibody molecules are promising candidates for targeted radionuclide-based imaging and therapy applications. Optimisation of targeting properties would permit the in vivo visualization of cancer-specific surface receptors with high contrast. In therapy, this may increase the ratio of radioactivity uptake between tumour and normal tissues. LÄS MER

  4. 13. EGFR- and HER2-Binding Affibody Molecules : Cellular studies of monomeric, dimeric and bispecific ligands

    Författare :Lina Ekerljung; Lars Gedda; Johan Lennartsson; Jörgen Carlsson; Birgitta Sundström; Uppsala universitet; []
    Nyckelord :EGFR; HER2; Affibody molecule; cell signaling; receptor dimerization; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Abnormal expression and signaling of the ErbB receptors is associated with the development and progression of several forms of cancer. In this thesis, new ErbB-targeting affibody molecules are evaluated regarding their cellular effects in vitro. LÄS MER

  5. 14. HER2-receptor quantification in breast cancer patients by imaging with ABY-025 Affibody and PET

    Författare :Ali Alhuseinalkhudhur; Henrik Lindman; Jens Sörensen; Mark Lubberink; Irina Velikyan; Rimma Axelsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET; Breast cancer; HER2; Affibody; ABY-025; Molecular imaging; Kinetic modelling; Brain metastasis;

    Sammanfattning : Breast cancer is the most common malignancy in women worldwide. Human epidermal growth factor receptor type 2 (HER2) is overexpressed in up to 20% of breast cancer cases and is considered an important prognostic factor and a therapeutic target. LÄS MER

  7. 15. Affibody molecules targeting HER3 for cancer therapy

    Författare :Tarek Bass; Stefan Ståhl; Christina Furebring; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affibody molecule; cancer therapy; epidermal growth factor receptors; ErbB3; HER3; protein engineering;

    Sammanfattning : The development of targeted therapy has contributed tremendously to the treatment of patients with cancer. The use of highly specific affinity proteins to target cancer cells has become a standard in treatment strategies for several different cancers. LÄS MER