Sökning: "proteolytic stability"

Visar resultat 1 - 5 av 36 avhandlingar innehållade orden proteolytic stability.

  1. 1. Investigations of chemical and enzymatic functionalization of affinity proteins

    Författare :Anders Myrhammar; Amelie Eriksson Karlström; Per-Åke Nygren; Christian Heinis; KTH; []
    Nyckelord :Affinity protein; affibody; conjugation; solid phase peptide synthesis; proteolytic stability; peptide nucleic acid PNA .; Bioteknologi; Biotechnology;

    Sammanfattning : AbstractAffinity proteins are important reagents in research, diagnostics and therapeutic settings. The focus of this thesis has been on investigating different chemical and enzymatic strategies for engineering of affinity proteins to generate affinity reagents with improved or changed functionality. LÄS MER

  3. 2. Lysosomal Membrane Stability and Cathepsins in Cell Death

    Författare :Hanna Appelqvist; Karin Öllinger; Katarina Kågedal; Petra Wäster; Maria Shoshan; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Lysosomes are acidic organelles that are critically involved in a number of physiological processes, including macromolecule degradation, endocytosis, autophagy, exocytosis and cholesterol homeostasis. Several pathological conditions, such as cancer, neurodegenerative disorders and lysosomal storage diseases, involve lysosomal disturbances, indicating the importance of the organelle for correct cellular function. LÄS MER

  4. 3. Processing, stability and interactions of lung surfactant protein C

    Författare :Jing Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mature SP-C is a 4.2 kDa transmembrane protein which is uniquely expressed in the alveolar type II cell. Human SP-C is generated via multistep proteolytic cleavage of both the C-terminal and Nterminal regions of proSP-C. LÄS MER

  5. 4. Modification of Surface Properties Through Polymer Adsorption. Kinetics, Interaction, Degradation and Stability

    Författare :Dries Muller; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TIRF.; protein; poly lactide ; poly ethylene oxide ; gelatin; exchange; enzyme; ellipsometry; desorption; degradation; adsorption; copolymers; Physical chemistry; Fysikalisk kemi;

    Sammanfattning : The interfacial behaviour of polymers in relation to surface modification and polymer degradation was studied. In the first part the interfacial behaviour of amphiphilic poly(ethylene oxide)–poly(D,L-lactide) (EmLn) diblock copolymers at hydrophilic and hydrophobic substrates from aquous solution was studied. LÄS MER

  7. 5. Studies on endoribonuclease RNase E and its role in RNA turnover

    Författare :Björn Sohlberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gene regulation RNA processing mRNA stability endoribonucleases RNase E AUUUA-motifs Archaea;

    Sammanfattning : RNA turnover is an important level of regulation of gene expression, by which a cell can rapidly adjust to changes in its environment. The turnover of RNA is done by an efficient but not well understood mechanism. LÄS MER