Sökning: "affibody"

Visar resultat 21 - 25 av 89 avhandlingar innehållade ordet affibody.

1. 21. Engineering of alternative scaffold derived drug conjugates and fusion-toxins for targeted cancer therapy

   Författare :Wen Yin; Torbjörn Gräslund; Serge Muyldermans; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HER2; Affibody; Cancer; ADAPT; Protein engineering; PE38; DM1; MMAE; MMAF; Biotechnology; Bioteknologi;

   Sammanfattning : Cancer is a major health problem, with premature death for many patients, and with a high monetary cost to society. The disease is complex to treat due to the many different types, but also because the disease-causing cells, that needs to be removed, are very similar to the normal cells. LÄS MER

3. 22. Affinity protein based inhibition of cancer related signaling pathways

   Författare :Erik Vernet; Torbjörn Gräslund; Antonino Cattaneo; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; cancer; endoplasmic reticulum retention; EGFR; HER2; IGF-1R; Raf; Ras; Bioengineering; Bioteknik;

   Sammanfattning : Dysregulation of protein activity, caused by alterations in protein sequence, expression, or localization, is associated with numerous diseases. In order to control the activity of harmful protein entities, affinity ligands such as proteins, oligonucleotides or small molecules can be engineered to specifically interact with them to modulate their function. LÄS MER

4. 23. PNA and affinity protein tools for selective tumor targeting of radiopharmaceuticals

   Författare :Hanna Tano; Amelie Eriksson Karlström; Per-Åke Nygren; Dario Neri; KTH; []
   Nyckelord :Cancer therapy; targeted radionuclide therapy; affinity proteins; Affibody molecules; CD38; GRPR; HER2; nanobody; peptide; PNA; RM26; pretargeting; Cancerterapi; radionuklid terapi; affinitetsproteiner; affibody molekyler; CD38; GRPR; HER2; nanobody; peptid; PNA; RM26; pretargeting; Biotechnology; Bioteknologi;

   Sammanfattning : Targeted radiotherapy of cancer intends to selectively deliver cytotoxic radionuclides to tumor cells. Affinity proteins of various kinds are explored for this task, and depending on the affinity protein used, different challenges arise. LÄS MER

5. 24. Bacterial display systems for engineering of affinity proteins

   Författare :Filippa Fleetwood; John Löfblom; Harald Kolmar; KTH; []
   Nyckelord :Combinatorial protein engineering; staphylococcal display; Affibody; biparatopic; VEGFR2; nanobody; E. coli display; autotransporter; Bioteknologi; Biotechnology;

   Sammanfattning : Directed evolution is a powerful method for engineering of specific affinity proteins such as antibodies and alternative scaffold proteins. For selections from combinatorial protein libraries, robust and high-throughput selection platforms are needed. LÄS MER

7. 25. Rational and combinatorial protein engineering for vaccine delivery and drug targeting

   Författare :Maria Wikman; Stefan Ståhl; Carl A. K. Borrebaeck; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; affibody; affinity chromatography; biotin; combinatorial; delivery; phage display; Biomedicin; Microbiology; Mikrobiologi;

   Sammanfattning : This thesis describes recombinant proteins that have been generated by rational and combinatorial protein engineering strategies for use in subunit vaccine delivery and tumor targeting.In a first series of studies, recombinant methods for incorporating immunogens into an adjuvant formulation, e.g. LÄS MER