Sökning: "Typer 1"

Visar resultat 21 - 25 av 689 avhandlingar innehållade orden Typer 1.

1. 21. Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes

   Författare :Yuedan Zhou; diabetes och endokrinologi Genomik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TCF7L2; rs7903146; Type 2 diabetes; β cell function; β cell survival; insulin secretion; proinsulin synthesis; proinsulin-to-insulin conversion; insulin maturation; open chromain; exon skipping; p53; TP53INP1; ISL1; MAFA; NEUROD1; PDX1; NKX6.1; PCSK1; PCSK2; SLC30A8; GWAS.;

   Sammanfattning : Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. LÄS MER

3. 22. Roles of protein kinase C in cell death and breast cancer

   Författare :Louise Cornmark; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; breast cancer; protein kinase C; apoptosis; cell death; Smac; Smac mimetics; IAP; stanniocalcin-1;

   Sammanfattning : Aberrant protein kinase C (PKC) activity and expression is implicated in different malignancies. To study the role of different PKC isoforms in breast cancer the expression of PCKα, δ and ε was evaluated in breast cancer tumors. In addition the effect of siRNA-mediated knockdown of the isoforms was studied in a global gene expression analysis. LÄS MER

4. 23. Retroviral gene transfer to repopulating hematopoietic cells

   Författare :Thomas Relander; Tumörmikromiljö; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GLVR-1; VSV-G; amphotropic; GALV; long-term bone marrow culture; NOD SCID; retroviral vector; hematopoietic stem cells; stem cells; gene transfer; gene therapy; fibronectin; Clinical genetics; Klinisk genetik;

   Sammanfattning : Hematopoietic stem cells (HSCs) have the capacity to maintain hematopoiesis throughout life. HSCs are ideal targets for permanent gene transfer, as the transgene will be expressed in all the progeny of the gene-modified stem cells. LÄS MER

5. 24. Tectonic implications of ca. 1.45 Ga granitoid magmatism at the southwestern margin of the East European Craton

   Författare :Audrius Cecys; Berggrundsgeologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Geologi; southern Sweden; fysisk geografi; physical geography; Mesoproterozoic; geochemistry; syntectonic; petrology; structural geology; anisotropy of magnetic susceptibility; Danopolonian orogeny; Geology; granite;

   Sammanfattning : Between ca 1.53 and 1.40 Ga, the southwestern margin of the East European Craton was subjected to extensive magmatism and deformation. While various suites of anorthositic, mangeritic and charnockitic-granitic rocks were emplaced between ca. LÄS MER

7. 25. Time is of the essence in speech perception! : Get it fast, or think about it

   Författare :Shahram Moradi; Jerker Rönnberg; Björn Lidestam; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Noise; auditory speech perception; audiovisual speech perception; hearing aids; Buller; hörsel; auditiv talperception; audiovisuell talperception; hörhjälpmedel;

   Sammanfattning : The present thesis examined the extent to which background noise influences the isolation point (IP, the shortest time from the onset of speech stimulus required for correct identification of that speech stimulus) and accuracy in identification of different types of speech stimuli (consonants, words, and final words in high-predictable [HP] and low-predictable [LP] sentences). These speech stimuli were presented in different modalities of presentation (auditory, visual, and audiovisual) to young normal-hearing listeners (Papers 1, 2, and 5). LÄS MER