Sökning: "long-term bone marrow culture"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden long-term bone marrow culture.

  1. 1. Characterization of HIV-1 RNA and DNA during long-term suppressive therapy

    Författare :Susanne von Stockenström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human immunodeficiency virus (HIV) is the virus causing acquired immune deficiency syndrome (AIDS). Since the discovery of HIV/AIDS over three decades ago, this disease has claimed millions of lives. One of the major accomplishments of modern history came in 1996, when combination antiretroviral therapy (cART) was introduced. LÄS MER

  3. 2. Peri-implantitis : treatment and effects of enamel matrix derivative

    Författare :Catrine Isehed; Pernilla Lundberg; Anders Holmlund; Leif Jansson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; implant; peri-implantitis; bone regeneration; enamel matrix derivative; surgical treatment; proteome; bone marrow macrophages; osteoclast formation; bone resorption; odontologi; Odontology;

    Sammanfattning : Biological complications affecting osseointegrated dental implants are a growing treatment problem in clinical practice. Since the number of implant carriers has increased in recent decades, this is an urgent topic in dentistry. LÄS MER

  4. 3. Hematopoietic stem cells: c-mpl and TNF receptor function

    Författare :Veslemøy Ramsfjell; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor necrosis factor-a.; in vivo reconstitution; ex vivo expansion; long-term bone marrow culture; differentiation; proliferation; synergy; Hematopoietic stem cells; thrombopoietin; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

    Sammanfattning : Hematopoietic stem cells (HSC) are crucial to life. Daily and throughout the life span of an individual they are responsible for replacing approximately 10(12) mature blood cells. Mature cells are, for example, required for transportation of oxygen, defense against infections and to stop bleeding. LÄS MER

  5. 4. Retroviral gene transfer to repopulating hematopoietic cells

    Författare :Thomas Relander; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GLVR-1; VSV-G; amphotropic; GALV; long-term bone marrow culture; NOD SCID; retroviral vector; hematopoietic stem cells; stem cells; gene transfer; gene therapy; fibronectin; Clinical genetics; Klinisk genetik;

    Sammanfattning : Hematopoietic stem cells (HSCs) have the capacity to maintain hematopoiesis throughout life. HSCs are ideal targets for permanent gene transfer, as the transgene will be expressed in all the progeny of the gene-modified stem cells. LÄS MER

  7. 5. Understanding the role of bone marrow niche in myeloid malignancies

    Författare :Monika Dolinska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Normal hematopoiesis is generated and maintained by rare hematopoietic stem cells (HSCs) through their capacity to self-renew and differentiate. This process is rigorously controlled, both by HSC-intrinsic molecular programs and extrinsic signals emitted by the local bone marrow (BM) microenvironment, the so-called HSC niche. LÄS MER