Sökning: "VSV-G"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet VSV-G.

  1. 1. Retroviral gene transfer to repopulating hematopoietic cells

    Författare :Thomas Relander; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GLVR-1; VSV-G; amphotropic; GALV; long-term bone marrow culture; NOD SCID; retroviral vector; hematopoietic stem cells; stem cells; gene transfer; gene therapy; fibronectin; Clinical genetics; Klinisk genetik;

    Sammanfattning : Hematopoietic stem cells (HSCs) have the capacity to maintain hematopoiesis throughout life. HSCs are ideal targets for permanent gene transfer, as the transgene will be expressed in all the progeny of the gene-modified stem cells. LÄS MER

  3. 2. The atypical Rho GTPase RhoD and its role in cellular dynamics

    Författare :Magdalena Blom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite its discovery 20 years ago, the accumulated knowledge about the Rho member RhoD is scarce. Instead, the vast majority of studies concerning Rho GTPases has focused on the three classical members RhoA, Cdc42 and Rac1. In contrast, RhoD is considered an atypical Rho GTPase, with an aberrant GTP/GDP cycling and an unknown regulation. LÄS MER

  4. 3. The role of RhoD in actin dynamics, receptor trafficking and cancer cell migration

    Författare :Vishal Nehru; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Ras subfamily of Rho GTPases plays an important role in myriads of cell processes, such as actin cytoskeleton dynamics, membrane trafficking and cell migration. Additionally, they also participate in diverse signal transduction pathways that regulate gene transcription, cell survival and cell growth. LÄS MER

  5. 4. Directed differentiation of adult neural stem cells for cell therapy in the nervous system

    Författare :Niklas Holmström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The emergence of neural stem cell research has raised hopes for cell therapy of neurological disorders. Insight into the normal mechanisms of neural stem cell fate specification and differentiation is a prerequisite for the development of safe and efficient clinical applications. LÄS MER

  7. 5. Hepatitis C virus. Aspects on natural history, antibody response, and viral quantification

    Författare :Martin Lagging; Göteborgs universitet; []
    Nyckelord :Hepatitis C virus; nosocomial infection; pseudotyped virus; fibrosis; viral quantification;

    Sammanfattning : Hepatitis C virus (HCV) is the major cause of parenterally transmitted non-A, non-B hepatitis, and is associated with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Despite the screening of blood products nosocomial spread of HCV continues to occur. LÄS MER