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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Simplified Routines for Sample Preparation and Analysis of Chemical Warfare Agent Degradation Products

    Författare :Raja Subramaniam; Calle Nilsson; Paula Vanninen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nerve agents; Alkyl alkylphosphonic acids; Solid phase derivatization; Fluorinated diazomethane reagent; High-energy collision induced dissociation; CID MS MS library; analytisk kemi; Analytical Chemistry;

    Sammanfattning : The thesis describes the development of new and improved methods for analyzing degradation markers from organophosphorus Chemical Warfare Agents (CWAs). Paper I and II describes an innovative and significantly improved method for the enrichment, derivatization (trimethysilylation) and GC-MS analysis of a broad range of organophosphorus CWAs degradation markers, namely the alkylphosphonic acids and a zwitterionic compound. LÄS MER

  3. 2. Development of methods for determining aflatoxins in biological material

    Författare :Anders Kussak; Rainer Stephany; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aflatoxins; Mycotoxins; Carcinogen; Airborne dust; Urine; Feed factories; Immunoaffinity extraction; Solid-phase extraction; Post-column derivatization; Electrospray; Mass spectrometry;

    Sammanfattning : In this thesis, it is shown how aflatoxins can be determined in biological material. The thesis is a summary of five papers.Aflatoxins are carcinogenic mycotoxins produced by Aspergillus moulds. Methods were developed for the determination of aflatoxins in samples of airborne dust and human urine collected at feed factories. LÄS MER

  4. 3. Applications of multi-component condensations and development of polyamine synthesis on solid-phase

    Författare :Daniel Jönsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Sammanfattning : Solid-phase synthesis of small non-polymeric molecules has become increasingly important as a tool in the development of pharmacologically active compounds. Of particular interest are the syntheses of compounds with low molecular weight, low polarity and a reduced flexibility of the functional groups, i.e. LÄS MER

  5. 4. Development and Validation of Bioanalytical Methods : Application to Melatonin and Selected Anti-Infective Drugs

    Författare :Susanne Römsing; Yngve Bergqvist; Åsa Emmer; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; african trypanosomiasis; melatonin; malaria; antiretroviral drugs; lumefantrine; tafenoquine; lamivudine; nevirapine; zidovudine; sampling paper; dried blood spots; capillary blood; antimalarial drugs; solid-phase extraction; liquid chromatography; Chemistry; Kemi; Analytical Chemistry; Analytisk kemi;

    Sammanfattning : This thesis describes bioanalytical methods for measuring melatonin and some anti-infective drugs in biological fluids. Solid-phase extraction (SPE) or protein precipitation was used for enrichment and purification of the analytes and Liquid Chromatography (LC) was used to analyze the samples. LÄS MER

  7. 5. Analytical Supercritical Fluid Extraction of Lipid Containing Samples

    Författare :Mattias Järemo; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SFC; extraction cell; liquid samples; fat retainers; lipids; SFE; carbon dioxide; Analytical chemistry; Analytisk kemi;

    Sammanfattning : Traditionally, sample work-up has been associated with different kinds of liquid extraction techniques involving a large consumption of hazardous solvents. There are today regulations that aims at replacement of dangerous chemicals which has created a need for new extraction techniques. LÄS MER