Sökning: "Ras biologi"

Visar resultat 6 - 10 av 25 avhandlingar innehållade orden Ras biologi.

  1. 6. Mating type switching and transcriptional silencing in Kluyveromyces lactis

    Författare :Emad Barsoum; Åström Stefan; Laura Rusche; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mating type switch; transcriptional silencing; alpha3; transposase; Ume6; Mts1; Ras; cAMP; K. lactis; Developmental biology; Utvecklingsbiologi; utvecklingsbiologi; Developmental Biology;

    Sammanfattning : To explore the similarities and differences of regulatory circuits among budding yeasts, we characterized the role of unscheduled meiotic gene expression 6 (UME6) and a novel mating type switching pathway in Kluyveromyces lactis. We found that Ume6 was required for transcriptional silencing of the cryptic mating-type loci HMLα and HMRa. LÄS MER

  3. 7. Colorectal cancer and radiation response : The role of EGFR, AKT and cancer stem cell markers

    Författare :Sara Häggblad Sahlberg; Bo Stenerlöw; Bengt Glimelius; Marika Nestor; Torgny Stigbrand; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; colorectal cancer; radiation; AKT; EGFR; cancer stem cells; CD133; CD44; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology;

    Sammanfattning : The primary treatment for colorectal cancer is surgery. Radiotherapy and chemotherapy, sometimes combined, are also frequently used to diminish recurrence risk. In response to radiation exposure, several cellular signaling cascades are activated to repair DNA breaks, prevent apoptosis and to keep the cells proliferating. LÄS MER

  4. 8. Drosophila immune responses in a model for epithelial hypertrophy

    Författare :Robert Krautz; Ulrich Theopold; Hugo Stocker; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Molecular Biology; molekylärbiologi;

    Sammanfattning : Apoptosis, differentiation and proliferation have to be tightly balanced and thus regulated to maintain tissue homeostasis. Stress, metabolic cues, genetic variability, infections and physiological host-commensal interactions influence this balance and thus need to be integrated. Therefore, beyond the discrimination between self and non-self (i.e. LÄS MER

  5. 9. Cell signaling by Rho and Miro GTPases : Studies of Rho GTPases in Cytoskeletal Reorganizations and of Miro GTPases in Mitochondrial Dynamics

    Författare :Åsa Fransson; Pontus Aspenström; Harry Mellor; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ras superfamily; Rho GTPases; cytoskeleton; Miro GTPases; mitochondrial dynamics; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : The Ras superfamily of GTPases embraces six major branches of proteins: the Ras, Rab, Ran, Arf, Rho and Miro subfamilies. The majority of GTPases function as binary switches that cycle between active GTP-bound and inactive GDP-bound states. This thesis will focus primarily on the biological functions of the Rho and Miro proteins. LÄS MER

  7. 10. The receptor tyrosine kinase Met and the protein tyrosine phosphatase PTPN2 in breast cancer

    Författare :Cynthia Veenstra; Olle Stål; Gizeh Perez-Tenorio; Pietras Kristian; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Breast cancer is the most common form of cancer in women worldwide and the second leading cause of cancer death. It is a heterogeneous disease and is subdivided into different subtypes, all with different treatment responses and survival outcomes. LÄS MER