Sökning: "alpha3"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet alpha3.

  1. 1. Mating type switching and transcriptional silencing in Kluyveromyces lactis

    Författare :Emad Barsoum; Åström Stefan; Laura Rusche; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mating type switch; transcriptional silencing; alpha3; transposase; Ume6; Mts1; Ras; cAMP; K. lactis; Developmental biology; Utvecklingsbiologi; utvecklingsbiologi; Developmental Biology;

    Sammanfattning : To explore the similarities and differences of regulatory circuits among budding yeasts, we characterized the role of unscheduled meiotic gene expression 6 (UME6) and a novel mating type switching pathway in Kluyveromyces lactis. We found that Ume6 was required for transcriptional silencing of the cryptic mating-type loci HMLα and HMRa. LÄS MER

  3. 2. Characterization and expression of subtypes of nicotinic receptors in brain and adrenal medulla : with focus on development, Alzheimer's disease and transgenic animal models

    Författare :Malahat Mousavi Tasouji; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cholinergic nicotinic receptors (nAChRs) seem to play an important role in numerous important physiological processes in brain as well as peripheral tissues of man. In first trimester human brain mRNA levels for the alpha3, alpha4, alpha5, alpha7, beta2, beta3, and beta4 nAChR subunits and binding sites were detected at 5 weeks of gestation. LÄS MER

  4. 3. The diverse role of laminin isoforms in neuronal cells, human mast cells and blood platelets

    Författare :Wondossen Sime; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Laminins; extracellular matrix; integrins; tooth pulp fibroblasts; mast cells; megakaryocytes; platelets; cell adhesion; cell migration; neurite outgrowth;

    Sammanfattning : The close interaction of cells with other cells and with extracellular matrix (ECM) components is a prerequisite in a number of biological activities. During development of the nervous system, axons often navigate a considerable distance depending on the type of molecular factors they encounter. LÄS MER

  5. 4. NK cell recognition of herpesviruses : mechanisms of viral immune escape

    Författare :Alexander Rölle; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Herpesviruses are ubiquitous pathogens which after an often asymptomatic infection establish lifelong latency in the host. Control of the viral infection depends on both innate and adaptive immune system. LÄS MER

  7. 5. Interactive mechanism between beta-amyloid process, alfa7 nicotinic receptor, glial cell activation and oxidative stress in Alzheimer's disease

    Författare :Wen-Feng Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Abeta; Alzheimer s disease; astrocytes; brain development; nAChRs; neuritic plaques oxidative stress; transgenic mice; knockout mice;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia with pathological features including the accumulation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs). These degenerative processes are also accompanied by impaired cholinergic transmission, oxidative stress, activated glia and inflammation reaction. LÄS MER