Sökning: "Ras biologi"

Visar resultat 21 - 25 av 25 avhandlingar innehållade orden Ras biologi.

1. 21. Novel functions of SMG-1 in carcinogenesis

   Författare :Evgenia Gubanova; Thomas Helleday; Andrei Gudkov; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molekylärgenetik; Molecular Genetics;

   Sammanfattning : Damage to DNA can cause mutations leading to cancer, and the DNA damage response (DDR), leading to transient cell-cycle arrest, DNA repair, senescence and apoptosis, plays a role in preventing tumor formation. At the same time, agents that damage DNA are used as anticancer therapy. LÄS MER

3. 22. Examining the role of metabolism in Myc-driven tumorigenesis

   Författare :Tacha Zi Plym Forshell; Jonas Nilsson; Mattias Belting; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cancer; Myc; metabolism; polyamines; spermidine synthase; glycolysis; lactate dehydrogenase; serine metabolism; Phgdh; folate metabolism; Shmt; Pim kinase; Pim-3 Kinase; Molecular biology; Molekylärbiologi;

   Sammanfattning : Myc transcriptionally regulates genes involved in processes such as cell proliferation, metabolism, differentiation, and angiogenesis.  MYC expression is deregulated in many types of human cancer; therefore discovering the mechanisms behind MYCs role in tumorigenesis is essential. LÄS MER

4. 23. RICH-1, a Multifunctional RhoGAP Domain-containing Protein, Involved in Regulation of the Actin Filament System and Membrane-trafficking

   Författare :Ninna Richnau; Pontus Aspenström; Carl-Henrik Heldin; Bengt Hallberg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Rho GTPase; RhoGAP; actin; BAR domain; membrane-trafficking; formin homology proteins; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : The Rho GTPases, which are related to the Ras family of proto-oncogenes, have been found to have important roles in regulating the morphogenic and migratory properties of eukaryotic cells. In addition, these proteins have been shown to regulate aspects of cell signaling, cell growth, cell division and cell survival. LÄS MER

5. 24. Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy

   Författare :Haisha Ma; Johan Lennartsson; Håkan Axelson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; Ras; macropinocytosis; Fer; STAT3; HD-PTP; Cbl; ubiquitination; pericyte; vasculature; tumor; ASKA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Sammanfattning : Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Therefore, it is of great importance to uncover the mechanisms that regulate PDGF/PDGFR signalling, to develop efficient inhibitors targeting this pathway. LÄS MER

7. 25. Adhesion Dependent Signals : Cell Survival, Receptor Crosstalk and Mechanostimulation

   Författare :Anjum Riaz; Staffan Johansson; Bengt Hallberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Integrins; Signal transduction; Protein kinase B; Akt; PI3K; Heparanase; ROS; Mechanosignalling; Molekylär cellbiologi; Molecular Cellbiology; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Cellforskning; Cell Research;

   Sammanfattning : The integrin family of cell surface receptors is evolutionary conserved and found in all multicellular animals. In humans 8-alpha and 18-beta integrins are non-covalently associated into 24 dimers. Integrins mediate cell-extracellular matrix and cell-cell interactions and participate in cell signalling. LÄS MER