Sökning: "Polymerase ?"

Visar resultat 1 - 5 av 391 avhandlingar innehållade orden Polymerase ?.

1. 1. RNA Polymerase I regulation by chromatin remodelling

   Författare :Yuan Guo; Ann-Kristin Östlund Farrants; Marikki Laiho; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA Pol I; ribosome genes; chromatin remodelling; WSTF; CHD4; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Cell proliferation and growth is correlated with effective protein synthesis and ribosome biogenesis. The transcription of the 47S pre-ribosomal RNA by RNA Polymerase I (RNA Pol I) machinery is the rate-limiting step of ribosome biogenesis and can accounts for more than 50% of total cellular transcription. LÄS MER

3. 2. Adseverin – An Immune-Specific Target of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

   Författare :Camilla Svensson; Lars Wärngård; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; 2; 3; 7; 8-Tetrachlorodibenzo-p-dioxin; TCDD; adseverin; aryl hydrocarbon receptor; immunotoxicity; thymus; cytoskeleton; Toxikologi; Toxicology; Toxikologi; Toxicology; toxikologi;

   Sammanfattning : The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces thymus atrophy and immunosuppression in all animal species examined and these effects constitute a potential risk to humans. TCDD can via binding to the intracellular aryl hydrocarbon receptor (AhR), modulate transcription of a number of genes and the aim of this thesis has been to identify such genes, which may explain the mechanisms behind TCDD-mediated immunotoxicity. LÄS MER

4. 3. Functional and structural properties of eukaryotic DNA polymerase epsilon

   Författare :Olga Chilkova; Erik Johansson; Per Elias; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; eukaryotic DNA replication; DNA polymerase epsilon; protein-DNA interaction; Biochemistry; Biokemi;

   Sammanfattning : In eukaryotes there are three DNA polymerases which are essential for the replication of chromosomal DNA: DNA polymerase alpha (Pol alpha), DNA polymerase delta (Pol delta) and DNA polymerase epsilon (Pol epsilon). In vitro studies of viral DNA replication showed that Pol alpha and Pol delta are sufficient for DNA replication on both leading and lagging DNA strands, thus leaving the function of Pol epsilon unknown. LÄS MER

5. 4. Estimation of acute toxicity by using the differentiated neuronal progenitor C17.2 cell model

   Författare :Jessica Lundqvist; Anna Forsby; Ann-Kristin Östlund Farrants; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neurotoxicity; C17.2; cell membrane potential; Optimisation culture condition; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : The authorities in Europe and United States request information regarding possible toxicity for substances that are produced in one tonne or more per year. Estimation of acute systemic toxicity is conducted in vivo using mice or rats. LÄS MER

7. 5. Regulation of Mammalian Poly(A) Polymerase Activity

   Författare :Ann-Charlotte Thuresson; Barklie Clements; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; poly A polymerase; PAP; polyadenylation; isoforms; phosphorylation; alternative splicing; CPSF interaction; aminoglycosides; Biomedicin; Microbiology; Mikrobiologi; Molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Poly(A) polymerase (PAP) is the enzyme catalyzing the synthesis of the adenine tail to the 3’-end of mRNA. This A-tail is present on the majority of the primary RNA transcripts of protein-coding genes, and is important for mRNA stability, export to the cytoplasm and translation. Therefore, PAP is a key regulator of eukaryotic gene expression. LÄS MER