Sökning: "thymus"

Visar resultat 1 - 5 av 84 avhandlingar innehållade ordet thymus.

  1. 1. Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus

    Detta är en avhandling från Mucosal Immunology, EMV, Lund University

    Författare :Katarzyna Sitnik; Lunds universitet.; Lund University.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thymus; mesenchymal cells; retinoic acid; thymic epithelial cells;

    Sammanfattning : T cells are key cellular components of the adaptive immune system that play a critical role in our defense against pathogens and cancer but also contribute to pathology in the setting of chronic inflammation and autoimmunity. The thymus constitutes the body's major T cell production site, where bone marrow-derived progenitors migrate in a co-ordinated fashion through anatomically distinct cortical and medullary regions that are composed of epithelial and mesenchymal stromal elements. LÄS MER

  2. 2. Inhibition of T cell responses to autoantigens and allergens by CD25+ regulatory T cells from thymus, cord and adult blood

    Detta är en avhandling från Mucosal Immunology, EMV, Lund University

    Författare :Kajsa Wing; Göteborgs universitet.; Gothenburg University.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tolerance; CD25 regulatory T cells; adult peripheral blood; cord blood; thymus; autoimmune disease; allergy;

    Sammanfattning : Autoimmune diseases and allergies are a growing problem in the western world today. Tolerance is primarily established by clonal deletion in the thymus. Despite this auto-reactive T cells are normally present in most individuals, which suggests that mechanisms of peripheral tolerance operate to silence potentially pathogenic T cells. LÄS MER

  3. 3. Generation of lymphocytes in the thymus : a study of morphologic, antigenic and functional development of lymphocytes in embryonic thymus organ cultures

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Roger Juhlin; Uppsala universitet.; [1977]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  4. 4. Characteristics and functions of thymic exosomes in human and mouse

    Detta är en avhandling från Göteborg : Kompendiet

    Författare :Gabriel Skogberg; Göteborgs universitet.; Gothenburg University.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Exosome; thymus; tissue-restricted antigen; Aire; Down syndrome;

    Sammanfattning : Thymocytes develop in the thymus to become a functional pool of T-cells in the periphery. To achieve this, the thymocytes go through several steps of maturation and selection within the thymus. LÄS MER

  5. 5. Adseverin – An Immune-Specific Target of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Camilla Svensson; Uppsala universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; 2; 3; 7; 8-Tetrachlorodibenzo-p-dioxin; TCDD; adseverin; aryl hydrocarbon receptor; immunotoxicity; thymus; cytoskeleton; Toxikologi; PHARMACY Toxicology; FARMACI Toxikologi; Toxicology; toxikologi;

    Sammanfattning : The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces thymus atrophy and immunosuppression in all animal species examined and these effects constitute a potential risk to humans. TCDD can via binding to the intracellular aryl hydrocarbon receptor (AhR), modulate transcription of a number of genes and the aim of this thesis has been to identify such genes, which may explain the mechanisms behind TCDD-mediated immunotoxicity. LÄS MER